Phenylethyl Resorcinol(CAS#85-27-8)
85-27-8 – Reference Information
| LogP | 2.11 at 22℃ |
| Overview | phenethyl Resorcinol is an effective whitening ingredient developed by Symrise, strong inhibition of tyrosinase activity, thereby reducing the production of melanin. Skin tests showed that 0.5% of the 377 concentration was more effective than kojic acid at 1% concentration without exposure to light. In 2012, the China Food and Drug Administration (SFDA) has approved the use of phenethyl resorcinol as a cosmetic raw material in cosmetics. |
| function | phenethyl Resorcinol is an effective whitening ingredient developed by Symrise, which has a strong antioxidant effect, strong inhibition of tyrosinase activity, thereby reducing the production of melanin. |
| Application | the chemical name of phenylethyl Resorcinol is 4-(1-phenylethyl)-1, 3-benzenediol, it is an effective ingredient with excellent whitening effect, which mainly achieves the whitening purpose by inhibiting the activity of tyrosinase. Existing research shows that phenethyl resorcinol can effectively whiten when used in an amount of more than 0.5%, and can also effectively resist oxidation and wrinkle. However, high concentrations of phenethyl resorcinol in cosmetics can cause skin allergy, the use limit in cosmetics is 0.5%, and the allergy problem makes it difficult to use large doses of phenethyl resorcinol, the more excellent whitening effect cannot be achieved. |
| preparation | add 0.2mol of 2, 4-diacetoxystyrene to a three-necked flask with stirring and add 4mol of benzene, 0.001mol of p-toluenesulfonic acid was added, and the temperature was raised to 80 ° C. And refluxed, and the temperature was maintained for 5 hours. Then, the temperature was lowered to 50 °c, 4mol of methanol was added, and the temperature was raised to 64 °c and refluxed for 1 hour. The solvent was then distilled off by atmospheric distillation. The residual material in the flask was recrystallized to obtain 32g of the product phenethyl resorcinol. The content was 99.5% and the yield was 80% as determined by liquid chromatography. |
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