4-CHLORO-7-NITROQUINAZOLINE(CAS#19815-17-9)
Introduction
Properties: It is a pale yellow crystal with strong hydrophobicity.Use:4-chloro-7-nitroquinazoline has a variety of applications in the field of chemistry. It can be used as an important intermediate in the synthesis of other compounds. It is also widely used in the preparation of insecticides and fungicides.Method:The preparation process of 4-chloro-7-nitroquinazoline can be started from quinazoline. The introduction of a chlorine group into the quinazoline molecule can be obtained by reacting with quinazoline by a chlorinating agent, for example, using ferrous chloride (FeCl2), and under appropriate conditions. Next, 4-chloroquinazoline reacts with nitric acid to prepare 4-chloro-7-nitroquinazoline.Safety Information:Specific safety information of 4-chloro-7-nitroquinazoline: such as toxicity and hazard, etc., need to refer to the corresponding Safety Data Sheet (SDS). When handling and using this compound, it is important to follow safe operating protocols and wear appropriate personal protective equipment.
Application
4-Chloro-7-nitroquinazoline (CAS 19815-17-9) is a privileged heterocyclic intermediate featuring a chloro group at the 4-position and a nitro group at the 7-position of the quinazoline core. This scaffold is widely used in medicinal chemistry for the synthesis of potent tyrosine kinase inhibitors, particularly EGFR (epidermal growth factor receptor), HER2, and VEGFR inhibitors for targeted cancer therapy. The chlorine at C4 undergoes facile nucleophilic aromatic substitution with amines, allowing rapid introduction of diverse aniline or aliphatic amine substituents to produce drug candidates such as gefitinib, erlotinib, and afatinib analogs. The nitro group can be reduced to an amino group, enabling further functionalization via amide or urea formation or serving as a handle for cross-coupling reactions. This building block is also utilized in developing antiviral, anti-inflammatory, and antimicrobial agents. Its high purity ensures reproducible results in high-throughput screening and scalable GMP processes. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key API intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
