7-BROMO-1H-QUINAZOLIN-4-ONE(CAS#194851-16-6)

Introduction

7-Bromoquinazolin-4(3H)-one is an organic compound.Properties: 7-Bromoquinazolin-4(3H)-one is a yellow to orange solid with benzene ring and pyrimidine ring structure. It is a highly polar compound that is soluble in polar solvents such as floor alcohol, dimethyl sulfoxide, etc.It can also be used as a synthetic raw material for pesticides, photosensitizers and pigments.Preparation method: 7-bromoquinazoline-4(3H)-ketone preparation methods are relatively diverse, the commonly used method is to react benzaldehyde with 3-bromoacetone under alkali conditions to generate the intermediate pyrimidine and oxidative bromination reaction, and finally obtain the target product by acid treatment.Safety information: 7-bromoquinazoline-4(3H)-one may have an irritating effect on the human body under certain conditions, and may cause irritation and damage to the eyes, skin and respiratory system. Exposure to dust, fumes or vapours should be avoided, and attention should be paid to ventilation in the workplace. Appropriate personal protective equipment such as glasses, gloves and protective clothing should be worn when in use. In case of contact, immediately rinse the affected area with plenty of water and seek medical attention.

Application
7-Bromo-1H-quinazolin-4-one (CAS 194851-16-6) is a functionalized quinazolinone derivative bearing a bromine atom at the 7-position and a lactam at the 4-position. This heterocyclic scaffold is a key intermediate in medicinal chemistry and drug discovery, particularly for the synthesis of potent tyrosine kinase inhibitors targeting EGFR, HER2, and VEGFR for non-small cell lung cancer, breast cancer, and other malignancies. The bromine enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl substituents, allowing rapid structure-activity relationship (SAR) studies. The 4-one tautomer provides hydrogen bond donor/acceptor sites, enhancing target affinity. This compound is also utilized in the development of antiviral, anti-inflammatory, antimicrobial, and anticonvulsant agents, as well as in agrochemical research. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis and contract manufacturing of 7-bromo-1H-quinazolin-4-one with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.