2-Amino-7-chloroquinazoline(CAS#190274-08-9)

 2-Amino-7-chloroquinazoline(CAS#190274-08-9)

Uses: It is an important intermediate in organic synthesis and has important applications in the field of medicinal chemistry. It can be used to synthesize compounds with potential biological activity, such as as as a key intermediate in the synthesis of some antibacterial and antitumor drugs, and obtain drug molecules with specific pharmacological effects by introducing different functional groups through structural modification and further reaction.
Safety information: Avoid inhaling dust or vapor and avoid contact with skin and eyes when using. In case of contact, rinse immediately with plenty of water and seek medical help.

Application
2-Amino-7-chloroquinazoline (CAS 190274-08-9) is a quinazoline derivative featuring an amino group at the 2-position and a chlorine at the 7-position. It serves as a versatile heterocyclic building block in medicinal chemistry, particularly for synthesizing tyrosine kinase inhibitors targeting EGFR, HER2, and VEGFR in non-small cell lung cancer, breast cancer, and other solid tumors. The reactive amino group enables amide, urea, or heterocycle formation, while the chlorine facilitates nucleophilic substitution or cross-coupling (Suzuki, Buchwald-Hartwig). This scaffold is also used to develop antiviral (e.g., hepatitis C), anti-inflammatory, and antimicrobial agents. High purity ensures reproducible results in drug discovery and SAR studies. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.