6-Chloroquinazoline-2,4(1H,3H)-dione(CAS#1640-60-4)

Application
6-Chloroquinazoline-2,4(1H,3H)-dione (CAS 1640-60-4) is a functionalized quinazoline derivative featuring a chlorine atom at the 6-position. This heterocyclic scaffold is a key intermediate in medicinal chemistry for the synthesis of potent tyrosine kinase inhibitors (e.g., EGFR, HER2, and VEGFR inhibitors) targeting non-small cell lung cancer, breast cancer, and other malignancies. The 2,4-dione system provides hydrogen bond donor/acceptor sites, enhancing target binding affinity. The chlorine enables selective cross-coupling or nucleophilic substitution for late-stage diversification. It is also utilized in developing antiviral, anti-inflammatory, and antimicrobial agents. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this API intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.