5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile(CAS#1015610-15-7)

Introduction

5-Fluoro-1H-pyrrolo[2,3-b]pyridin-4-nitrile is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of the compound:Quality:- Appearance: 5-fluoro-1H-pyrrolo[2,3-b]pyridine-4-nitrile is a white solid or crystalline substance.- Solubility: It has a certain solubility in some organic solvents (such as ethanol, dimethyl sulfoxide, dimethylformamide, etc.).Use:Method:- The preparation of 5-fluoro-1H-pyrrolo[2,3-b]pyridine-4-nitrile can be carried out in a variety of ways. A common preparation method is obtained by reacting pyrrolo[2,3-b]pyridine with a cyanophil compound with an active nucleophilic group.Safety Information:- The compound should be kept sealed and dry during storage, avoiding contact with substances such as oxygen, moisture, and strong acids.- 5-Fluoro-1H-pyrrolo[2,3-b]pyridin-4-nitrile may be potentially harmful to the environment and should be used and handled under reasonable control in accordance with relevant environmental regulations.- When using or handling the compound, follow relevant regulations and safe operating procedures.

Application
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (CAS 1015610-15-7) is a functionalized azaindole derivative bearing a fluorine atom at position 5 and a nitrile group at position 4. As a purine bioisostere, this heterocyclic scaffold is extensively used in medicinal chemistry for the development of selective kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK, and TBK1 inhibitors). The fluorine enhances metabolic stability and binding affinity, while the nitrile serves as a versatile handle for further derivatization via reduction to amine, hydrolysis to carboxylic acid, or cycloaddition reactions. This building block enables rapid structure-activity relationship (SAR) studies and the construction of focused drug-like libraries. High purity ensures reproducible results in high-throughput screening and scalable pharmaceutical synthesis. It also finds applications in agrochemical research and as a precursor for labeled compounds. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.