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5-Fluoro-4-Iodo-1H-Pyrrolo[2,3-B]Pyridine(CAS#1015610-23-7)
Introduction
5-Fluoro-4-iodo-1H-pyrrolo[2,3-b]pyridine is an organic compound.Quality:- Appearance: 5-fluoro-4-iodo-1H-pyrrolo[2,3-b]pyridine is a white to yellowish solid.- Solubility: Soluble in common organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM).Use:5-Fluoro-4-iodo-1H-pyrrolo[2,3-b]pyridine is often used as an intermediate in organic synthesis.Method:The preparation of 5-fluoro-4-iodo-1H-pyrrolo[2,3-b]pyridine can be achieved through a variety of pathways. A common method is to synthesize it through a proper chemical reaction.Safety Information:- Care should be taken to prevent inhalation, skin contact, and ingestion of 5-fluoro-4-iodo-1H-pyrrolo[2,3-b]pyridine during storage and handling. Personal protective measures, such as wearing protective eyewear and gloves, must be in place to ensure that the laboratory is well ventilated.- The use and handling of this compound needs to be carried out in accordance with proper operating procedures and laboratory safety handling guidelines, and in compliance with relevant regulations. The safety data sheet (SDS) of the chemical should be read carefully and the appropriate safety procedures should be followed before use.
Application
5-Fluoro-4-iodo-1H-pyrrolo[2,3-b]pyridine (CAS 1015610-23-7) is a multifunctional heterocyclic building block containing both a fluorine atom and an iodine atom on the azaindole core. The iodine enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira, Ullmann), while the fluorine improves metabolic stability and target binding affinity. As a purine bioisostere, this scaffold is extensively used in medicinal chemistry for the development of selective kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK, TBK1, and PI3K). The orthogonal reactivity allows sequential functionalization to rapidly explore structure-activity relationships (SAR) and construct drug-like libraries. High purity ensures reproducible results in high-throughput screening and scalable pharmaceutical synthesis. It also finds applications in agrochemical research and as a precursor for labeled compounds. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
