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5-Chloro-1H-Pyrrolo[2,3-B]Pyridine-4-Carbaldehyde(CAS#1015610-39-5)
Introduction
5-Chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxaldehyde is an organic compound.- In organic synthesis, it can be used as an important functional group and building block.Method:The preparation method of 5-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxaldehyde can be carried out by the following steps:- 5-bromo-1H-pyrrolo[2,3-b]pyridine-4-carboxaldehyde is obtained by substitution reaction with the corresponding bromopyrrole[2,3-b]pyridine.- Then, 5-bromo-1H-pyrrolo[2,3-b]pyridine-4-carboxaldehyde is reacted with phosphorus pentachloride to replace the bromine atom with the chlorine atom to give 5-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxaldehyde.Safety Information:- 5-Chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxaldehyde is generally considered to have low toxicity under general conditions of use.- Inhalation, ingestion, or contact with skin and eyes should be avoided during handling.- When storing and handling, relevant safety measures and operating procedures should be observed.- For specific safety information: refer to the Safety Data Sheet (SDS) for the compound.
Application
5-Chloro-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde (CAS 1015610-39-5) is a functionalized azaindole derivative bearing a chlorine atom at position 5 and an aldehyde group at position 4. This heterocyclic scaffold serves as a versatile building block in medicinal chemistry and drug discovery, particularly for the synthesis of selective kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK, and TBK1 inhibitors). The aldehyde enables reductive amination, condensation, or Wittig reactions to introduce diverse side chains, while the chlorine allows nucleophilic aromatic substitution or cross-coupling (Suzuki, Buchwald-Hartwig). As a purine bioisostere, this intermediate facilitates rapid structure-activity relationship (SAR) studies and the construction of focused compound libraries. High purity ensures reproducible results in high-throughput screening and scalable pharmaceutical synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
