Methyl 2-bromomethyl-3-nitrobenzoate （CAS# 98475-07-1)

Introduction

Methyl 2-bromomethyl-3-nitrobenzoate.

Quality:

1. Appearance: colorless liquid or white crystalline solid;

4. Density: about 1.6-1.7 g/ml;

5. Solubility: soluble in organic solvents, such as alcohols, ethers and ketones.

Use:

Methyl 2-bromomethyl-3-nitrobenzoate is often used as an intermediate of pesticides, can be used in the synthesis of pesticides such as methyl besylsulfonylcarboxyl, and can also be used as a synthetic intermediate of glyphosate.

Method:

Methyl 2-bromomethyl-3-nitrobenzoate can be prepared by chloromethylation and nitrification. The specific steps are as follows: methyl benzoate is reacted with acetic acid and phosphorus trichloride at low temperature to obtain methyl 2-chloromethylbenzoate; Then, methyl 2-chloromethylbenzoate is introduced into the nitro group by nitrification of lead nitrate to give methyl 2-bromomethyl-3-nitrobenzoate.

Safety Information:

1. Methyl 2-bromomethyl-3-nitrobenzoate is flammable at high temperature and open flame, so high temperature and open flame should be avoided.

2. Wear chemical protective glasses and gloves when using to avoid contact with skin and inhalation of gases.

4. When storing, it should be sealed and kept away from heat, fire and oxidants.

Application

Methyl 2-bromomethyl-3-nitrobenzoate (CAS 98475-07-1) is a versatile organic building block that serves as a critical intermediate in pharmaceutical and agrochemical synthesis. In pharmaceutical R&D, it is a key precursor for the synthesis of anti-tumor and anti-inflammatory drug candidates. As Lenalidomide Impurity 5 (also known as Lenalidomide Impurity 46), it is an essential certified reference standard for analytical method development (AMD), method validation (AMV), and quality control (QC) in Abbreviated New Drug Applications (ANDA) and during the commercial production of Lenalidomide. This product is used as a reference standard with traceability against USP or EP pharmacopeial standards. In agrochemical synthesis, it is utilized as an intermediate for pesticides such as methyl besylsulfonylcarboxyl and as a synthetic intermediate for glyphosate. The reactive bromomethyl and nitro functional groups enable participation in coupling, substitution, and other organic reactions, making it valuable for laboratory R&D and the synthesis of new chemical entities. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high‑purity compound with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.