3,4-dichloropyridazine(CAS#1677-80-1)

Introduction

3,4-Dichloropyridazine is an organic compound. It is found in colorless crystalline or light yellow solid form and has a pungent odor. The following is an introduction to the properties, uses, preparation methods and safety information of 3,4-dichloropyridazine:Quality:Appearance: Colorless crystalline or light yellow solidDensity: 1.75 g/mlSolubility: Soluble in organic solvents such as ethanol, chloroform, dimethyl ether and benzeneUse:Catalyst: It can be used as a ligand for transition metals, as one of the components of catalysts, and plays an important role in catalytic reactions.Method:3,4-Dichloropyridazine can be synthesized by:Chlorination of pyridazine: Piperidine chloride is prepared by reacting pyridazine with chlorine gas.Chlorination reaction: The chloride of piperidine is chlorinated with ferric chloride (FeCl3) or phosphorus pentachloride (PCl5).Safety Information:3,4-Dichloropyridazine is an organic compound and should be handled in accordance with laboratory safety procedures.It is an irritating substance that may have an irritating effect on the skin, eyes, and respiratory tract. Appropriate personal protective equipment such as gloves, protective eyewear, and appropriate respirators should be worn when using.It should be stored in an airtight container, away from ignition and oxidants, and avoid contact with strong acids, strong alkalis and other substances.When handling and disposing of, relevant environmental protection regulations and management requirements should be observed.

3,4-Dichloropyridazine (CAS 1677-80-1) is a high-purity heterocyclic building block with two reactive chlorine atoms at the 3- and 4-positions. It is widely used in medicinal chemistry for the synthesis of potent kinase inhibitors (e.g., JAK, BTK, CDK), antiviral, antibacterial, and anti-inflammatory agents. The dichloro substitution enables sequential nucleophilic aromatic substitution and palladium-catalyzed cross-coupling (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), allowing rapid diversification for SAR studies. In agrochemical research, it serves as a key precursor for herbicides, fungicides, and insecticides with enhanced bioavailability and crop safety. Its rigid pyridazine core provides optimal target engagement and metabolic stability. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 3,4-dichloropyridazine from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.