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3,9-Divinyl-2,4,8,10-tetraoxaspiro[5.5]undecane(CAS#78-19-3)

Chemical Property:

Molecular Formula C11H16O4
Molar Mass 212.24
Density 1.251g/mLat 25°C(lit.)
Melting Point 43-46°C(lit.)
Boling Point 108-110°C2mm Hg(lit.)
Flash Point >230°F
Solubility almost transparency in Methanol
Vapor Presure 0.00512mmHg at 25°C
Appearance powder to lump
Color White to Almost white
Storage Condition under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index 1.4389 (estimate)

Product Detail

Product Tags

Safety Description 24/25 - Avoid contact with skin and eyes.
WGK Germany 2
RTECS XF0875000
HS Code 29329990

 

Introduction

3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]undecane, also known as DOTMA, is an oxygenated heterocyclic compound. The following is an introduction to its nature, use, preparation and safety information:Quality:- Appearance: DOTMA is generally a white crystalline solid.- Solubility: DOTMA is soluble in organic solvents such as dimethyl sulfoxide (DMSO), dichloromethane and ethanol, etc., and insoluble in water.Use:- Chemical reagents: DOTMA can be used as a specific organic synthesis reagent, mainly used as a catalyst or ligand in organic synthesis reactions.Method:The preparation method of DOTMA is relatively complex and requires high experimental conditions and technical requirements. A common preparation method is by performing a ring fusion reaction on diethyl dichloroacetate under suitable conditions.Safety Information:The relevant safety information of DOTMA is limited, and further research and experiments need to refer to chemical safety guidelines and individual experimental conditions. In general, proper laboratory protocols and appropriate personal protective measures should be followed when handling DOTMA, avoiding direct contact with the skin and eyes.

Application
3,9-Divinyl-2,4,8,10-tetraoxaspiro[5.5]undecane is a high-purity spiroacetal monomer containing two vinyl groups, functioning as an acetal-type crosslinking agent. In pharmaceutical R&D, it is used to synthesize acid-degradable core-crosslinked micelles and biocompatible copolymers for targeted drug delivery and controlled release of therapeutics like indomethacin. In polymer chemistry, it serves as a crosslinker in radical emulsion copolymerization of 2-hydroxyethyl methacrylate and in the fabrication of hydrophilic cross-linked polystyrene matrices for solid-phase peptide synthesis. In construction materials, its cyclic structure enhances the dispersibility and water-reducing efficiency of cross-linked polycarboxylate superplasticizers, improving cement fluidity, hydration retardation, and concrete compressive strength. Xinchem offers flexible custom synthesis and contract manufacturing of this versatile building block, supporting research and industrial applications from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.


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