4-Amino-2,6-dichloropyridine(CAS#2587-02-2)
Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
4-Amino-2,6-dichloropyridine(CAS#2587-02-2) introduction
4-Amino-2,6-dichloropyridine. The following is an introduction to its properties, uses, manufacturing methods and safety information:
Quality:
- Appearance: 4-Amino-2,6-dichloropyridine is a colorless to yellow crystal or crystalline powder.
- Solubility: It has low solubility in water and high solubility in organic solvents such as ethanol, ether, and benzene.
- Stability: It is a stable compound, but decomposition may occur at high temperatures or in contact with strong oxidizing substances.
Use:
- Chemical reagents: 4-amino-2,6-dichloropyridine can be used as a reagent in organic synthesis, such as the analysis of amino acids and anabolites.
Method:
- 4-Amino-2,6-dichloropyridine can be prepared by reducing 4-amino-2,6-dichloropyridic acid (raw material). The reducing agent can be sulfoxide or sodium nitrite.
Safety Information:
- 4-Amino-2,6-dichloropyridine will produce toxic gases under certain conditions, and care should be taken to operate under well-ventilated conditions when operating.
- Avoid contact with skin, eyes, and respiratory tract.
- Follow proper storage and handling practices to avoid unsafe reactions with other chemicals.
Application
4-Amino-2,6-dichloropyridine (CAS 2587-02-2) is a multifunctional heterocyclic building block widely used in pharmaceutical and agrochemical research. The presence of an amino group and two reactive chlorine atoms enables selective nucleophilic aromatic substitution and palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), allowing rapid construction of diverse 2,4,6-trisubstituted pyridine libraries. This scaffold serves as a key intermediate for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK inhibitors), as well as antiviral, antibacterial, and antifungal agents. In agrochemical development, it is utilized to prepare selective herbicides, fungicides, and insecticides with improved crop protection profiles. Its rigid, electron-deficient pyridine core enhances metabolic stability and target binding affinity, facilitating structure-activity relationship (SAR) studies and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 4-amino-2,6-dichloropyridine with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
