4-(1-Pyrrolidinylsulfonylmethyl)Aniline(CAS#334981-10-1)
Introduction
4-Aniline is an organic compound with the chemical formula C13H18N2O2S. The following is a detailed description of its nature, use and preparation method:
Properties: 4-(Aniline) is a white solid powder. Its structure contains benzene ring and pyrrolidine ring, has good solubility, can be dissolved in common organic solvents.
Uses: 4-(-) Aniline is often used as a pharmaceutical intermediate with antibacterial and antiviral activity. It can be used to synthesize a variety of biologically active molecules, such as drugs, pesticides, etc.
Preparation method: The preparation of 4-(-) Aniline is usually completed by a two-step reaction. First, methanesulfonyl chloride and 4-aminoanisole are reacted to produce a sulfonyl compound. Then, the sulfonyl compound is reacted with pyrrolidine to obtain the target product.
Safety information: 4-(-) Aniline is an organic compound, you need to pay attention to its safe operation. Wear appropriate personal protective equipment such as goggles and gloves during operation. Avoid contact with the skin and inhalation of its powder, should be in a well-ventilated place to operate. In case of contact or ingestion, seek medical attention immediately.
Application
4-(1-Pyrrolidinylsulfonylmethyl)aniline (CAS 334981-10-1) is a versatile sulfonamide-containing aniline derivative widely used as a key pharmaceutical intermediate in drug discovery and medicinal chemistry. The sulfonylmethyl group linked to a pyrrolidine ring provides a unique hydrogen-bond acceptor motif, while the primary aniline allows facile derivatization via amide coupling, reductive amination, or heterocycle formation (e.g., benzimidazoles, quinazolines). This scaffold is particularly valuable in the synthesis of selective kinase inhibitors, including those targeting BTK, JAK, and CDK families for cancer and autoimmune disease therapies. It also serves as a building block for antimicrobial agents, anti-inflammatory compounds, and CNS drug candidates. The compound’s sulfonamide moiety enhances metabolic stability and solubility. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis and contract manufacturing of this high-purity intermediate with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.
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