((2S,3S)-2-(benzyloxy)pentan-3-yl)hydrazine(2S,3S)-2,3-bis(benzoyloxy)succinate(CAS#183871-36-5)
Introduction
(S-(R',R'))-2,3-bis (benzoyloxy) succinic acid (abbreviated TBOA) is an organic compound with the chemical formula C19H18O6. It is a solid, colorless crystal or white powder with a special fragrance.
TBOA has antibacterial and insecticidal activity, so it is widely used as a pesticide and antibacterial agent in the agricultural field. In addition, it is also used as a reagent in pharmaceutical research and organic synthesis.
The preparation method of TBOA is to react benzoyl chloride and succinic acid to obtain benzoyl succinic acid, and then control the reaction under appropriate conditions to obtain the desired stereoisomer.
About (S-(R',R'))-(1-ethyl-2-(phenylmethoxy) propyl) hydrazine (EBH for short) is an organic compound, the chemical formula is C11H17N3O. It is a colorless liquid, soluble in alcohol and ether at room temperature.
EBH has reducibility and curability. It is widely used as a photosensitive material and curing agent, and is used in the electronics industry to prepare photosensitizers and visible light hardening adhesives.
The preparation method of EBH is to condense benzyl bromide with acetic acid formaldehyde, and then reduce the amide to obtain the desired product.
When using these two compounds, you need to pay attention to their safety. TBOA may cause irritation when in contact with skin and eyes, inhalation and chewing should be avoided. EBH is also irritating to the skin and eyes and should be used with caution. When using these compounds, follow appropriate laboratory safety practices and take the necessary personal protective measures. If there is an accident, immediately wash the affected parts, and timely medical treatment.
Application
((2S,3S)-2-(Benzyloxy)pentan-3-yl)hydrazine (2S,3S)-2,3-bis(benzoyloxy)succinate (CAS 183871-36-5) is a high-purity chiral pharmaceutical intermediate, commonly known as Posaconazole Intermediate 4. This hydrazine salt is a key building block in the commercial synthesis of Posaconazole, a broad-spectrum triazole antifungal agent used to treat invasive fungal infections such as aspergillosis and candidiasis. The compound features two defined stereocenters and a dibenzoyl tartaric acid complex, ensuring enantiomeric purity for the production of optically active APIs. Beyond its role in antifungal drug development, this versatile intermediate serves as a chiral precursor for other triazole antifungals and bioactive molecules. Its hydrazine moiety enables selective functionalization, making it valuable in medicinal chemistry for constructing complex heterocyclic scaffolds. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity intermediate, supporting pharmaceutical R&D, method validation, and commercial API production with flexible scaling from grams to metric tons.
