1-Bromo-3-methoxypropane(CAS#36865-41-5)
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 2344 |
| HS Code | 29033990 |
| Hazard Class | IRRITANT |
| Packing Group | Ⅲ |
Introduction
1-bromo-3-methoxypropane, also known as 1-bromo-3-methoxypropane, is an organic compound. Its chemical formula is C4H9BrO and its molecular weight is 153.02. Properties: 1-bromo-3-methoxypropane is a colorless liquid with a special odor. Its density is 1.36 g/cm3, its boiling point is 132 °C, and its melting point is -75 °C. It is soluble in organic solvents such as alcohols, ethers, and ketones, and insoluble in water. Uses: 1-bromo-3-methoxypropane is commonly used as a reagent and intermediate in organic synthesis. It can be used in the synthesis of a variety of functional compounds, such as esters, ethers, alcohols, etc. It can also be used as a precursor for surfactants, dyes, and fragrances. Preparation method: The preparation of 1-bromo-3-methoxypropane can be obtained by reacting 1-bromo-3-chloropropane with methanol. The reaction is usually carried out under alkaline conditions, such as using sodium carbonate or sodium hydroxide as a catalyst. Safety information: 1-Bromo-3-methoxypropane is irritating and corrosive. Protective measures such as gloves, goggles, and protective clothing should be taken when using. Avoid inhaling its vapors and avoid contact with skin and eyes. Open flames and static electricity should be avoided during storage and handling. When disposing of waste, we must comply with relevant environmental regulations. In case of inhalation or exposure, seek immediate medical attention.
Application
1-Bromo-3-methoxypropane (3‑bromopropyl methyl ether) is a versatile alkylating reagent and organic building block used in pharmaceutical, agrochemical, and fine chemical research. It serves as a key intermediate for introducing the 3‑methoxypropyl group into target molecules via nucleophilic substitution and cross‑coupling reactions. In medicinal chemistry, this compound enables the synthesis of β‑adrenergic antagonists (e.g., alprenolol analogs), histamine H₂ receptor antagonists, and other bioactive drug candidates. Its utility extends to the preparation of heterocyclic scaffolds such as piperidines, pyrazoles, and imidazoles, which are core structures in antiviral, anticancer, and anti‑inflammatory agents. As a certified reference material, it is employed in analytical method development for impurity profiling and quality control. In agrochemical R&D, it acts as an intermediate for herbicides and insecticides. Its high purity ensures reproducible results in structure‑activity relationship studies and cGMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high‑purity 1‑bromo‑3‑methoxypropane with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.


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