(1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride(CAS#168960-19-8)

Introduction

(1S,4R)-(4-aminocycloent-2-enyl) methanol hydrochloride (also known as AMCHA) is an organic compound with the chemical structure:

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Nature:

AMCHA is a colorless or white solid, relatively stable at room temperature. It is a heterocyclic compound with stereoisomerism. Its melting point is 180-184 ° C, and its solubility is good. It is a basic compound, soluble in water and organic solvents.

Use:

AMCHA in the form of hydrochloride is often used as a pharmaceutical intermediate, especially in the synthesis of antiviral and anticancer drugs. It can also be used in organic synthesis reactions such as carbonylation reactions and condensation reactions.

Method:

The preparation of AMCHA is usually obtained by Amine bonding reaction of cyclopentene methanol. The specific procedure is to react cyclopentene methanol with an appropriate amine (such as ammonia) under basic conditions, and then crystallize and purify the resulting product to obtain AMCHA.

Safety Information:

AMCHA is generally safe under correct use, but it is still a chemical and needs to be handled with caution. Contact with skin, eyes or inhalation of AMCHA dust may cause irritation. It is recommended to use personal protective equipment, such as laboratory gloves and protective glasses, during operation. During handling and storage, AMCHA should be kept away from flammable substances and oxidizing agents. In the process of use, storage and disposal, should comply with the relevant safety procedures and regulations.

Application
(1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride is a high-purity chiral heterocyclic primary amine hydrochloride, serving as a critical pharmaceutical intermediate and versatile building block. As the key structural precursor in the synthesis of Abacavir (Ziagen®), a potent carbocyclic 2′-deoxyguanosine nucleoside reverse transcriptase inhibitor (NRTI) for treating HIV-1 and HIV-2 infection, its stereochemically controlled bicyclic framework enables the efficient, scalable synthesis of antiviral carbocyclic nucleosides. Beyond Abacavir manufacture, this rigid, enantiopure aminocyclopentene scaffold is extensively utilized in medicinal chemistry for constructing constrained peptide mimics, CNS drug candidates, and a new class of nucleoside antibiotics. Xinchem offers reliable custom synthesis and flexible contract manufacturing of this pharmaceutical building block, supporting method validation (AMV), ANDA filings, impurity profiling (Abacavir Impurity 2), and commercial API production with GMP compliance, scaled from R&D to commercial tons. Contact us for a competitive quote.