Product Name and CAS Number

2,5-Hexanedione Acetonylacetone | CAS 110 13 4

One Line Sourcing Position

High purity 2,5-Hexanedione for heterocyclic synthesis and pharmaceutical research applications.

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Specification

Purity by GC: 99.0 percent minimum, typical batch 99.2 to 99.5 percent
Appearance: Clear colorless to pale yellow liquid
Melting point: -6 to -5 degrees Celsius
Boiling point: 191 degrees Celsius
Density at 25 degrees Celsius: 0.973 g per mL
Refractive index nD20: 1.425 to 1.428
Flash point: 78 degrees Celsius (closed cup)
Water content Karl Fischer: 0.10 percent maximum
Assay by titration: 98.5 to 101.0 percent
Heavy metals: Less than 10 ppm
Stock Status: In Stock in US warehouse and China hub

Available Quantity and Lead Time

Regular supply: 100 g to 20 metric tons per shipment
Lead time: 2 to 5 days for standard packaging; bulk orders require 7 to 10 days

Document Support

COA SDS HPLC chromatogram NMR spectrum Mass spectrum MS available upon request

Application

2,5-Hexanedione is a versatile diketone building block widely used in organic synthesis and pharmaceutical research. It is a key starting reagent for Diels-Alder cycloaddition reactions, enabling the construction of complex six-membered ring systems. In heterocyclic chemistry, it reacts with amines to yield 2,5-dimethylpyrroles, which are important scaffolds for pharmaceutical intermediates and agrochemicals. The compound is also employed in the preparation of trans-2,5-dimethylpyrrolidine and plays a crucial role as a protecting agent for amino groups in amino sugars and nucleosides. In the flavor and fragrance industry, 2,5-hexanedione serves as a fragrance component and a precursor for specialty aroma chemicals. It is used as a high boiling point solvent for synthetic resins, nitro spray paints, printing inks, leather tanning agents, and rubber vulcanization accelerators. Additionally, it is a key intermediate in the synthesis of five-membered heterocycles including indane-type and benzannulated systems. In analytical chemistry, 2,5-hexanedione is used as a reference standard for the determination of n-hexane metabolite exposure in biological monitoring.

Custom Synthesis Support

We offer custom synthesis for 2,5-hexanedione derivatives including substituted diketones, chiral pyrrolidines, and isotopically labeled versions. Share your technical datasheet for feasibility review.

Packaging and Shipping

Available in 500 mL, 1 L, 5 L, 25 L HDPE drums, or 200 L steel drums. Custom packaging such as amber glass bottles with PTFE lined caps is supported. Fastest dispatch within 7 days after order confirmation. DOT Classification: UN2810, Toxic liquids, organic, n.o.s. (2,5-hexanedione), 6.1, PG III. Store in a cool, dry, well ventilated area away from heat, spark and direct sunlight. Stable but incompatible with strong oxidizing agents, strong bases, and strong reducing agents.

Why XinChem

XinChem provides 2,5-hexanedione with strict control of purity and water content for US customers. Our ISO 9001 certified facility monitors every batch by GC and Karl Fischer analysis, ensuring consistent reactivity for heterocyclic synthesis and pharmaceutical research. We maintain a buffer stock of 5 metric tons in US warehouses for emergency deliveries within 48 hours. Each order includes a full documentation package: COA, SDS, GC chromatograms, and NMR spectra accessible through our online portal. Our technical support team assists with handling under inert atmosphere, stability optimization, and regulatory compliance including TSCA, EINECS, and REACH exemptions. For contract customers, we offer quarterly price locks and consignment inventory to reduce supply chain risk. Trusted by over 150 pharmaceutical and fine chemical companies in North America. We also provide free sample evaluation for qualified R&D projects and a price match guarantee against any valid competitor quote for equivalent quality.

FAQ

Q1 How should 2,5-hexanedione be stored safely?
A Store in a cool, dry, well ventilated area away from ignition sources, strong oxidizing agents, strong bases, and strong reducing agents. Keep container tightly sealed. Shelf life is 24 months under recommended conditions.

Q2 What purity grades do you supply?
A Standard grade is 99.0 percent by GC. We also supply 99.5 percent and 99.8 percent grades for pharmaceutical intermediate and certified reference standard applications.

Q3 Is 2,5-hexanedione miscible with water?
A Yes, it is fully miscible with water as well as with alcohols, diethyl ether, and most organic solvents.

Q4 Do you provide sample quantities for synthesis development?
A Yes, free samples of 100 mL are available for qualified US companies. Shipping fee applies for small quantities.

Q5 What are the common impurities in 2,5-hexanedione and how do you control them?
A Key impurities include mono methyl substituted diketones, oligomers, and water. Our specification limits total impurities below 0.5 percent with full GC profiling per batch.

Q6 Can you supply 2,5-hexanedione under inert atmosphere for moisture sensitive applications?
A Yes, we offer nitrogen purged packaging and can supply with molecular sieves for additional moisture control. Please specify your requirements.