2-Amino-5-bromopyridine(CAS#1072-97-5)
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 2 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29333999 |
| Hazard Class | IRRITANT |
Introduction
2-Amino-5-bromopyridine is a brown solid. It is a derivative of pyridine and has amino and bromo-group functional groups. The following is an introduction to the properties, uses, preparation methods and safety information of 2-amino-5-bromopyridine:- Properties:- Appearance: 2-amino-5-bromopyridine is a brown solid. - Solubility: Slightly soluble in water, soluble in organic solvents such as methanol, ethanol and chloroform. Uses:- Chemical reagent: 2-amino-5-bromopyridine can be used as a reagent in organic synthesis, such as as as an intermediate in the synthesis of aromatic amines. Preparation method: -2-amino-5-bromopyridine can be prepared by a variety of methods. One of the commonly used methods is to react 2-bromopyridine with ammonia to produce 2-amino-5-bromopyridine. Safety Information:-2-Amino-5-bromopyridine has no significant safety issues reported under general conditions of use. - As a chemical, personal protective measures such as gloves, safety glasses, and a lab coat should be taken when using it. - When operating, avoid direct contact with the skin and inhalation of its particles. - It should be stored in a dry, well-ventilated place, away from fire and flammable materials. - Appropriate laboratory protocols and safety standards should be followed during use.
Application
2-Amino-5-bromopyridine is a functionalized heterocyclic building block used as a key intermediate in pharmaceutical and agrochemical research. The bromine at the 5-position enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl groups, while the amino group allows amide, urea, or sulfonamide formation. This scaffold is widely used in the synthesis of kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK inhibitors), as well as antiviral, antibacterial, and antifungal agents. Its rigid pyridine core enhances metabolic stability and target binding affinity. In agrochemical research, it serves as a precursor for herbicides and fungicides. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
