2-Bromo-4-cyanopyridine(CAS#10386-27-3)
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| UN IDs | UN3439 |
| Hazard Class | 6.1 |
| Packing Group | III |
Introduction
2-Bromo-4-cyanopyridine is an organic compound with the chemical formula C7H4BrN. The following is an introduction to its nature, use, formulation and safety information:
Properties: 2-Bromo-4-cyanopyridine is a colorless to pale yellow crystalline solid. It is stable at room temperature, but may decompose when heated. It is soluble in organic solvents such as ethanol and acetone and insoluble in water.
Purpose: 2-Bromo-4-cyanopyridine is an important intermediate in organic synthesis. It can be used to prepare a variety of biologically active compounds, including pesticides, pharmaceuticals and dyes.
Production method: 2-bromo-4-cyanopyridine can be obtained by reacting 2-bromo-4-iodopyridine with sodium cyanide. First, 2-bromo-4-iodopyridine is reacted with sodium cyanide under basic conditions to form 2-bromo-4-cyanopyridine, and then the product is acidified with acid to obtain a pure product.
Safety Information: 2-Bromo-4-cyanopyridine is an organic compound that is potentially hazardous. Appropriate safety measures are required during handling and use, including wearing protective gloves, eye protection and protective clothing. Avoid inhalation, contact with skin and eyes, and ensure that the operation is carried out in a well-ventilated place. When stored, it should be kept in a sealed container, away from fire and oxidizing agents. In case of poisoning, seek medical help immediately.
Application
2-Bromo-4-cyanopyridine (CAS 10386-27-3) is a versatile heterocyclic building block used extensively in medicinal chemistry and pharmaceutical research. The bromine at the 2-position enables selective palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl substituents, while the nitrile at the 4-position allows further functionalization to amides, amidines, or tetrazoles. This scaffold is a key intermediate for synthesizing potent kinase inhibitors, antiviral agents (e.g., HIV integrase inhibitors), and antibacterial compounds. Its electron-deficient pyridine ring enhances target binding affinity and metabolic stability. In agrochemical research, it serves as a precursor for herbicides and fungicides. Additionally, it is used in the preparation of fluorescent probes and functional materials. High purity ensures reproducible results in high-throughput screening, SAR studies, and scalable GMP manufacturing. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and dependable global supply.
