(S)-N-Boc-3-Amino-3-phenylpropanoic acid(CAS#103365-47-5)

(S)-N-Boc-3-Amino-3-phenylpropanoic acid(CAS#103365-47-5) Brief introduction

S-Boc-β-phenylalanine, the full name of N-propionyl-protected β-phenylalanine, is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of the compound:

Quality:
S-Boc-β-phenylalanine is a white to yellowish crystalline powder that is soluble in some polar organic solvents. It contains a protecting group (Boc group) in its chemical structure that protects the amino group of β-phenylalanine from unwanted reactions.

Use:
S-Boc-β-phenylalanine is commonly used in organic synthesis as an intermediate or starting material. By deprotecting the Boc group, the reexposed amino group can be involved in other reactions, resulting in the preparation of various β-phenylalanine derivatives and similar compounds.

Method:
In general, the preparation method of S-Boc-β-phenylalanine is to react β-phenylalanine with propionyl chloride to generate the corresponding amide, and further use butoxycarbonyl salt (Boc2O) to react with it to obtain the desired product.

Safety Information:
S-Boc-β-Phenylalanine is generally relatively safe under normal operating conditions, but care is still required to follow good laboratory safety practices. It can be irritating to the skin and eyes and should be avoided in direct contact when used. Avoid inhaling its powder as it may cause respiratory irritation. In case of any discomfort or accident, you should seek medical attention promptly. During storage, it should be kept in a dry, well-ventilated place and avoid contact with oxidants and strong acids.

Application
(S)-N-Boc-3-amino-3-phenylpropanoic acid (CAS 103365-47-5) is a high-purity, optically active β-amino acid derivative with a Boc-protected amine. As a versatile pharmaceutical intermediate, it serves as a key chiral building block for the synthesis of biologically active compounds, including peptidomimetics, protease inhibitors (e.g., HIV-1 protease, renin), and antiviral agents. The rigid β-phenyl scaffold enhances metabolic stability and target selectivity. In medicinal chemistry, this compound is widely used to construct constrained peptide analogs and small-molecule drug candidates for diabetes, cardiovascular diseases, and neurological disorders. Its orthogonal protecting group (Boc) allows selective deprotection under mild acidic conditions, facilitating solid-phase peptide synthesis and solution-phase drug discovery. High enantiopurity (≥98%) ensures reproducible results in SAR studies, high-throughput screening, and GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential chiral building block with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and reliable global supply.