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1H-Indazole-6-carboxylic acid(CAS#704-91-6)

Chemical Property:

Molecular Formula C8H6N2O2
Molar Mass 162.15
Density 1.506±0.06 g/cm3(Predicted)
Melting Point 302-307 °C
Boling Point 443.7±18.0 °C(Predicted)
Flash Point 222.172°C
Vapor Presure 0mmHg at 25°C
Appearance Crystalline powder
Color White to light brown
pKa 4.01±0.30(Predicted)
Storage Condition Sealed in dry,Room Temperature
Refractive Index 1.743
MDL MFCD06804571

Product Detail

Product Tags

WGK Germany 3
HS Code 29339980
Hazard Class IRRITANT

 

Introduction

1H-Indazole-6-carboxylic acid is an organic compound with the chemical formula C9H6N2O2. The following is a description of its nature, use, formulation and safety information:

 

Nature:

1H-Indazole-6-carboxylic acid is a solid substance with colorless to light yellow crystals. It is slightly soluble in water and alcoholic solvents in humid air, but insoluble in non-polar solvents such as petroleum ether. It has weak acidity.

 

Use:

1H-Indazole-6-carboxylic acid, as a chemical reagent, can be used as a catalyst in organic synthesis reactions, such as reacting with organic ketones to form new compounds. It is also used in the synthesis of biologically active indazole compounds, which have potential applications in the field of medicine.

 

Preparation Method:

1H-Indazole-6-carboxylic acid can react with aniline and acetic anhydride to generate indazole compounds, and then obtain the target product through acidic hydrolysis.

 

Safety Information:

There is limited safety information about 1H-Indazole-6-carboxylic acid, but it is an organic compound, so the basic safety procedures for organic compounds should generally be followed. Avoid skin contact and inhalation, and should be handled in a well-ventilated area. Wear appropriate protective gloves and safety glasses when using. If inhaled or ingested, seek medical attention immediately.

Application
1H-Indazole-6-carboxylic acid (CAS 704-91-6) is a privileged heterocyclic building block widely used in medicinal chemistry and pharmaceutical research. Its indazole core serves as a bioisostere of indole and purine, making it a valuable scaffold for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases, including inhibitors of FGFR, PI3K, and CDK families. The carboxylic acid group at the 6-position enables facile amide and ester formation, allowing rapid derivatization for structure-activity relationship (SAR) studies and the construction of diverse drug-like libraries. This intermediate is also employed in the development of PARP inhibitors, antiviral agents, and antibacterial compounds. Its rigid, electron-rich indazole ring enhances metabolic stability and target binding affinity. In agrochemical research, derivatives are used to develop herbicides and fungicides. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.


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