![5H-Pyrrolo[3,2-d]pyrimidine,7-bromo-4-methoxy-5-[(phenylmethoxy)methyl](CAS#299916-62-4) Featured Image](https://www.xinchem.com/uploads/pyrimidinebromomethoxyphenylmethoxymethyl.png)
5H-Pyrrolo[3,2-d]pyrimidine,7-bromo-4-methoxy-5-[(phenylmethoxy)methyl](CAS#299916-62-4)
In the field of medicinal chemistry, such compounds may be used as potential pharmaceutical intermediates in the synthesis of biologically active pharmaceutical molecules. For example, the pyrrolopyrimidine structure plays an important role in the development of some antitumor, antiviral, and antimicrobial drugs, and substituents such as bromide atom at position 7, methoxy group at position 4, and benzethoxymethyl group at position 5 may affect the affinity and selectivity of compounds for specific targets. In organic synthetic chemistry, it can be used as a special structural unit for the construction of more complex organic molecules, providing new substrates and ideas for the study of organic synthesis methodology.
Physical and chemical properties: At present, there are few data on its specific physical and chemical properties such as melting point, boiling point, density, and solubility in public information. However, it can be speculated that due to the presence of bromine atoms, methoxy groups, and benzene rings in the molecule, it may have a certain degree of fat solubility, which may have better solubility in organic solvents and relatively poor solubility in water. At the same time, its melting point may be affected by intermolecular forces and crystal structure, and due to the complexity of the molecular structure, there may be a variety of interactions between molecules, and the melting point may be high.
Application
5H-Pyrrolo[3,2-d]pyrimidine,7-bromo-4-methoxy-5-[(phenylmethoxy)methyl] (CAS 299916-62-4) is a key pharmaceutical intermediate and specialized organic compound utilized in drug discovery and development. The compound features a bromine atom at the 7-position, a methoxy group at the 4-position, and a benzyloxymethyl (BOM) protecting group at the 5-position of the pyrrolo[3,2-d]pyrimidine core, providing an orthogonal handle for complex synthetic transformations. This pyrrolopyrimidine scaffold is a privileged structure known for its ability to bind within the ATP-binding pocket of kinase domains, allowing it to serve as an advanced building block for the synthesis of novel kinase inhibitors. This heterocyclic intermediate is specifically employed in the synthesis of promising anticancer agents, antiviral therapeutics, and targeted antimicrobial drugs. The BOM protecting group ensures selective deprotection under mild conditions, facilitating efficient assembly of complex molecular architectures during API development. It can be further functionalized via palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, to rapidly generate diverse compound libraries for structure-activity relationship studies. As a customizable solution, Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity this advanced pharmaceutical building block, supporting flexible scaling from R&D research to commercial production. Contact us for a competitive quote.
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