page_banner

product

ETHYL 1H-INDAZOLE-7-CARBOXYLATE(CAS#885278-74-0)

Chemical Property:

Molecular Formula C10H10N2O2
Molar Mass 190.2
Melting Point 111-113℃
Appearance Crystalline powder
Storage Condition Sealed in dry,Room Temperature

Product Detail

Product Tags

 

Introduction

ETHYL 1H-INDAZOLE-7-CARBOXYLATE IS AN ORGANIC COMPOUND. Its properties are as follows:Appearance: Ethyl 1H-indazole-7-carboxylic acid is a white solid.Solubility: It is soluble in organic solvents such as methanol, ethanol and dimethyl sulfoxide.What it is used for:Pesticide R&D: 1H-indazole-7-carboxylate ethyl ester is also used in pesticide R&D, such as insecticides and fungicides.There are generally a variety of ways to prepare ethyl 1H-indazole-7-carboxylate, and one of the commonly used methods is as follows:Indazole is reacted with dimethyl sulfoxide by heating to give 1, 3-dimethylindazole. Then, 1, 3-dimethylindazole was esterified with diethyl carbonate under alkaline conditions to obtain the target product 1H-indazole-7-carboxylic acid ethyl ester.When using and handling ethyl 1H-indazole-7-carboxylate, the following safety information should be noted:Avoid direct contact: Avoid direct contact with the substance on the skin, eyes, and respiratory system.Use ventilation equipment: When handling this compound, ensure that there is adequate ventilation to avoid its vapor accumulation indoors.Storage conditions: When storing, 1H-indazole-7-carboxylate ethyl ester should be placed in a cool, dry and sealed container, away from fire sources and flammable materials.Waste disposal: When disposing of this compound, follow local waste disposal regulations and do not dump it into the sewer or natural environment.When using this compound, it is important to follow the relevant safety operating procedures to ensure personal and environmental safety.

Application
Ethyl 1H-indazole-7-carboxylate (CAS 885278-74-0) is a versatile heterocyclic building block widely used in medicinal chemistry and drug discovery. The indazole core is a privileged scaffold in pharmaceutical research, serving as a bioisostere for indole and purine. The ethyl ester group at the 7-position allows facile hydrolysis to the carboxylic acid or reduction to the alcohol, enabling rapid derivatization for structure-activity relationship (SAR) studies. This intermediate is a key precursor for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases, including FGFR, PI3K, CDK, and PARP inhibitors. It is also employed in the development of antiviral, antibacterial, and antifungal agents. Its rigid, electron-rich indazole ring enhances metabolic stability and target binding affinity. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.


  • Previous:
  • Next:

  • Write your message here and send it to us