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Tert-Butyl3-Iodo-1H-Pyrrolo[2,3-B]Pyridin-5-Ylcarbamate(CAS#1015609-19-4)
Introduction
Tert-Butyl3-Iodo-1H-Pyrrolo[2,3-B]pyridin-5-ylcarbamate is an organic compound.Properties of the compound:Appearance: A solid styleSolubility: Soluble in organic solvents such as dichloromethane, dimethyl sulfoxide and dimethylformamide, but insoluble in water.Use of Tert-Butyl3-Iodo-1H-Pyrrolo[2,3-B]Pyridin-5-ylcarbamate:This compound is often used as an intermediate in organic synthesis for the preparation of other organic compounds.Preparation method of Tert-Butyl3-iodo-1H-pyrrolo[2,3-B]pyridin-5-ylcarbamate:There may be a variety of ways to make it, but the most common method is through chemical synthesis. One method is to react 3-Iodo-1H-Pyrrolo[2,3-B]Pyrridine with tert-Butyl carbamate to obtain the target compound.Safety information of Tert-Butyl3-iodo-1H-pyrrolo[2,3-B]pyridin-5-ylcarbamate:The specific safety information of the compound: including toxicity, corrosivity and other data, it is necessary to refer to the relevant safety literature and data. When performing experiments or applications, proper laboratory protocols should be followed and appropriate personal protective equipment should be provided. The storage and disposal of chemicals also need to be carried out in accordance with the appropriate regulations and guidelines.
Application
Tert-Butyl 3-iodo-1H-pyrrolo[2,3-b]pyridin-5-ylcarbamate (CAS 1015609-19-4) is a functionalized azaindole derivative (7-azaindole) bearing a Boc-protected amine at position 5 and an iodine atom at position 3. This scaffold is widely used as a key intermediate in medicinal chemistry and drug discovery. As a purine bioisostere, it enables the synthesis of highly selective kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK, TBK1, and PI3K families). The Boc group provides orthogonal protection for the amine, allowing selective deprotection under acidic conditions, while the iodine facilitates efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira, Ullmann) to introduce diverse aryl, heteroaryl, or alkyl substituents. This building block is essential for rapid structure-activity relationship (SAR) studies and the construction of focused compound libraries. It also finds applications in the synthesis of antiviral agents, CNS drugs, and agrochemicals. High purity ensures reproducible results in high-throughput screening and scalable pharmaceutical synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
