3-bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine(CAS#1190321-08-4)

Introduction

3-Bromo-6-chloro-7-azaindole is an organic compound. It is a pyrrolopyroxidine compound with substituents of bromine, chlorine, and nitrogen atoms.The properties of this compound include:- Appearance: Colorless to light yellow crystals- Soluble: Soluble in common organic solvents such as ethanol, acetone and methylene chloride- It can be used as an intermediate in the synthesis of organic compounds for the preparation of other compounds with similar structures.The preparation of 3-bromo-6-chloro-7-azaindole can be obtained by a variety of methods, one of the most common is by reacting a substrate of pyrrolopyridine with oxides or reagents of bromine and chlorine.Safety information: Compounds have bromine and chlorine atoms, which can be toxic and dangerous. Laboratory safety operating procedures should be followed and good ventilation should be maintained.

Application
3-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine (CAS 1190321-08-4) is a functionalized 7-azaindole derivative bearing orthogonal halogen leaving groups at the 3- and 6-positions. This heterocyclic scaffold serves as a versatile building block in medicinal chemistry and drug discovery, particularly for the synthesis of selective kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., JAK, BTK, CDK, and TBK1 inhibitors). The bromine at C3 is preferentially reactive in palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), while the chlorine at C6 allows nucleophilic aromatic substitution or sequential cross-couplings, enabling rapid structure-activity relationship (SAR) studies. As a purine bioisostere, this core is also utilized in antiviral research, CNS drug development, and agrochemical synthesis. High purity ensures reproducible results in high-throughput screening and scalable pharmaceutical manufacture. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.