3-Bromo-1H-indole-4-carbonitrile(CAS#1186663-64-8)
Introduction
3-Bromo-4-cyano-1H-indole is an organic compound. The following is an introduction to its nature, use, manufacturing methods and safety information:Quality:- Appearance: 3-Bromo-4-cyano-1H-indole is a colorless to light yellow crystal or crystalline solid.- Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide and methylene chloride.Use:- 3-Bromo-4-cyano-1H-indole can be used as an intermediate in organic synthesis.Method:- The preparation method of 3-bromo-4-cyano-1H-indole can be based on indole.- 3-bromophenylboronic acid and tris(dimethylamine)stannous were added to the reaction solvent for cross-coupling to obtain 3-bromopyridine.- Then, 3-bromopyridine is reacted with zinc cyano to produce 3-bromo-4-cyano-1H-indole.Safety Information:- The specific uses and application fields of 3-bromo-4-cyano-1H-indole may be different, and further research and evaluation are needed for its detailed safety information.- When handling and using the compound, appropriate precautions such as wearing protective eyewear and gloves to ensure good indoor ventilation are required.- The compound should be stored in a sealed, dry, cool place, away from ignition and oxidants.
Application
3-Bromo-1H-indole-4-carbonitrile (CAS 1186663-64-8) is a functionalized indole derivative bearing a bromine at position 3 and a nitrile at position 4. This heterocyclic scaffold is widely used in medicinal chemistry and drug discovery for the synthesis of selective kinase inhibitors, G-protein coupled receptor (GPCR) modulators, and anticancer agents. The bromine enables efficient cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl groups, while the nitrile group serves as a versatile handle for further derivatization via reduction to amine, hydrolysis to carboxylic acid, or cycloaddition reactions. As a rigid, planar building block, it facilitates structure-activity relationship (SAR) studies and the construction of focused drug-like libraries. High purity ensures reproducible results in high-throughput screening and scalable pharmaceutical synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this key intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
