4-Hydroxyacetophenone CAS 99-93-4
Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S37/39 - Wear suitable gloves and eye/face protection S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | PC4959775 |
| TSCA | Yes |
| HS Code | 29145000 |
| Hazard Note | Irritant |
99-93-4 - Reference
| Reference
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1. Yu Honghong, Gao Xiaoyan. Based on UPLC-Q-TOF/MS ~ E, rapid analysis of chemical constituents in mianyinchen [J]. Cen... |
| Overview | p-hydroxyacetophenone, because its molecule contains hydroxyl and ketone groups on the benzene ring, therefore, it is often used as an intermediate in organic synthesis to react with other compounds to synthesize many important substances. Generally used for the synthesis of pharmaceutical intermediates (α-bromo-p-hydroxyacetophenone, choleretic drugs, antipyretic analgesics and other drugs), Other (spices, feed, etc.; Pesticides, dyes, liquid crystal materials, etc.). |
| Application | p-hydroxyacetophenone is white needle-like crystal at room temperature, naturally occurring in the stems and leaves of Artemisia scoparia, in the roots of plants such as ginseng baby Vine. It can be used in the manufacture of choleretic drugs and other raw materials for organic synthesis. |
Application
4-Hydroxyacetophenone is a versatile phenolic compound widely utilized as a pharmaceutical intermediate in the synthesis of analgesics (e.g., paracetamol), anti-inflammatory drugs, and the bronchodilator salbutamol. With inherent choleretic activity, it also serves as a hepatoprotective agent for gall bladder conditions, and its derivatives demonstrate cholinesterase inhibition for Alzheimer's research and anti-HBV effects. In cosmetic science, it functions as a mild, ECOCERT-approved preservative and antioxidant, stabilizing creams, sunscreens, lotions, and shampoos while acting as a synergistic emulsifier. It also serves as a building block for fragrances (FEMA 3524) and flavors, and as an intermediate in agrochemicals, dyes, and polymer chemistry. Xinchem offers flexible custom synthesis and contract manufacturing of high-purity 4-hydroxyacetophenone, with reliable global supply scaled from R&D to commercial tons. Contact us for a competitive quote today.
