Ethyl 5-chloro 1-2-4 triazolo 4-3-a pyriMidine-7-carboxylate CAS 99951-90-3

Ethyl 5-chloro-[1,2,4]triazolo[4,3-a]pyrimidine-7-carboxylate (CAS 99951-90-3) is a fused triazolo-pyrimidine scaffold that serves as a versatile building block for pharmaceutical research and custom chemical synthesis. It functions as a heterocyclic inhibitor, primarily targeting ATF4 and NF-κB proteins, and has been shown to inhibit protein synthesis in tumor cells, demonstrating anticancer activity by suppressing cancer cell growth. The compound exhibits neuroprotective and anti-inflammatory properties by reducing nitric oxide (NO) and TNF-α production in LPS-stimulated human microglia, and downregulating ER stress markers such as BIP and cleaved caspase-3 in neuronal cells, making it a promising lead for neurodegenerative disorders (e.g., Alzheimer’s, Parkinson’s). Its reactive chloro and ester groups enable further functionalization via cross-coupling, nucleophilic substitution, or hydrolysis to the carboxylic acid, facilitating rapid structure-activity relationship (SAR) studies. Xinchem offers reliable custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity heterocyclic intermediate with flexible scaling from R&D to commercial tons. Contact us for a competitive quote and global supply.