4,6-Dichloro-5-iodopyrimidine(CAS#1137576-38-5)

Introduction

4, is an organic compound with the chemical formula C4H2Cl2IN3. Its properties are as follows:

1. Appearance: 4. It is a colorless to pale yellow solid.

2. Solubility: It can be dissolved in organic solvents, such as ethanol, dimethylformamide and dichloromethane, but its solubility in water is relatively low.

4. It has a wide range of applications in organic synthesis, some of which include:

1. chemical reagent: it can be used as a reagent for organic synthesis reaction, such as catalyst, crosslinking agent, etc.

2. Drug research: In the field of drug research, this compound may be used to synthesize new drugs or as an intermediate for drugs.

Preparation 4, the method of: usually involves the following steps:

1. 1,3-dichloro -5-iodobenzene (1,3-Dichloro-5-iodobenzene) reacts with ammonia.

2. The reaction product reacts with trichloroammonium cyanurate to produce the expected product 4.

Regarding safety information, since 4, is a chemical substance, the following items should be paid attention to during operation:

1. Avoid contact with skin and eyes: When using chemical reagents, wear appropriate personal protective equipment such as protective gloves, glasses and laboratory coats.

2. avoid inhalation: during operation, avoid inhaling its dust and vapor. It is best to operate in a well-ventilated area and use appropriate personal protective equipment and facilities.

3. Storage and handling: Store chemicals in sealed containers, away from fire and high temperatures. Observe local waste disposal regulations when disposing of waste.

Application
4,6-Dichloro-5-iodopyrimidine (CAS 1137576-38-5) is a highly functionalized pyrimidine building block bearing two chlorine atoms and one iodine atom. This unique ortho-dihalo substitution pattern enables chemoselective, sequential cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira, Negishi) at the iodine site first, followed by chlorine displacement, allowing rapid construction of trisubstituted pyrimidine libraries. It is widely used in medicinal chemistry for the synthesis of potent kinase inhibitors (e.g., JAK, BTK, CDK, PI3K), antiviral agents (e.g., HIV integrase inhibitors), and anticancer drug candidates. The rigid pyrimidine core provides excellent metabolic stability and target affinity. This intermediate also serves in agrochemical research for herbicide and fungicide development. High purity ensures reproducible SAR studies and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this advanced heterocyclic intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.