tert-butyl (S)-3-(4-bromophenyl)piperidine-1-carboxylate)(CAS#1476776-55-2)

Introduction

Nirapani tosylate is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of niraparib tosylate:Quality:Nirapani tosylate is a white solid with a specific structure and chemical properties. Nirapani toluene sulfonate is achiral, i.e., its two enantiomers have the same properties.Use:Nirapani tosylate has important applications in the field of organic synthesis. It can be used as an intermediate in the synthesis of other chemicals.Method:The preparation of niraparib tosylate is usually carried out by organic synthesis methods. A common synthesis method is to react 4-bromophenol with S-saturated tributylheptanol under suitable conditions to generate nirapani toluene sulfonate.Safety Information:Niraparib tosylate has limited safety information and requires proper safety measures to be followed when using and handling. Contact with skin and eyes should be avoided, and kept away from fire. Appropriate protective equipment, such as gloves and protective glasses, should be worn during use. In case of accidental exposure or ingestion, seek medical attention immediately and show the chemical information to the doctor. When storing, niraparib tosylate should be stored in a dry, well-ventilated place away from ignition and flammable substances.

Application
(S)-tert-Butyl 3-(4-bromophenyl)piperidine-1-carboxylate (CAS 1476776-55-2, Niraparib Intermediate 1) is a high-purity, chiral piperidine building block. Its rigid bromophenyl-Boc structure serves as a key pharmaceutical intermediate and essential scaffold for the convergent synthesis of Niraparib (MK‑4827), a clinical PARP inhibitor, via a Buchwald-Hartwig cross-coupling strategy. As an anticancer drug intermediate, it is used to construct targeted covalent inhibitors for oncology research, while also serving as a versatile organic synthesis intermediate for producing focused heterocyclic libraries and agrochemicals. This advanced pharmaceutical intermediate allows reliable custom synthesis and flexible contract manufacturing to support seamless scale-up from R&D to commercial GMP production. Contact Xinchem today for a competitive quote and global supply.