2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene（CAS# 92878-95-0)
Introduction
2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene is an organic compound with the following properties and uses:
Quality:
- Appearance: White to pale yellow crystals
Use:
- The compound can be used as an intermediate in organic synthesis for the preparation of other compounds
Method:
2-(3-chloropropoxy)-1-methoxy-4-nitrobenzene can be produced by synthesis under appropriate conditions. The specific synthesis method can be adjusted according to the chemical reaction conditions and requirements.
Safety Information:
- The compound is an organonitrate compound, which is a volatile organic compound, and should be avoided from inhalation or contact with the skin and eyes
- Wear appropriate personal protective equipment such as gloves, goggles, etc. when operating
- It should be operated in a well-ventilated area to avoid the production of harmful gases or vapors
- It should be stored properly to avoid dangers caused by high temperatures, fire, etc
Application
2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene (CAS 92878-95-0) is a key pharmaceutical intermediate. It is specifically recognized as an indispensable building block in the synthesis of Bosutinib (SKI-606), a tyrosine kinase inhibitor used for the treatment of chronic myelogenous leukemia (CML). Its precise ortho-methoxy and para-chloropropoxy substitution pattern is non-negotiable for the correct regioselective transformation to the quinoline core of the drug. Substituting this compound with analogs will derail the synthetic pathway.
In addition to its role as a synthetic precursor, this compound serves as a certified impurity standard (Bosutinib Impurity 9/20/21). It is essential for quality control (QC) and regulatory submissions, such as Abbreviated New Drug Applications (ANDA), supporting Bosutinib API manufacturing.
Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene. Contact us for a competitive quote and reliable global supply.
