5-Bromoindole-2-carboxylic acid(CAS#7254-19-5)
7254-19-5 – Risk and Safety
| Hazard Symbols | Xi – Irritant |
| Risk Codes | 36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 – Wear suitable gloves and eye/face protection S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29339980 |
| Hazard Class | IRRITANT |
7254-19-5 – Introduction
Nature:
-Appearance: acid is a white to yellowish crystalline solid.
-Solubility: It is soluble in some organic solvents at room temperature, such as dimethyl sulfoxide and dimethylformamide.
Use:
-acid is a commonly used organic synthesis intermediate, commonly used in the synthesis of drugs, pesticides and dyes and other compounds.
Preparation Method:
-or acid can be prepared by the following steps:
1. Starting from indole, bromination reaction is carried out with bromine gas under alkaline conditions, and bromine is added to the C5 position on the indole ring to obtain 5-bromoindole.
2. then 5-bromo indole and cyanoacetate reaction, nucleophilic addition occurs, generating 5-bromo indole -2-carboxylic acid ethyl ester.
3. Finally, hydrolyze ethyl 5-bromoindole-2-carboxylate to obtain acid.
Safety Information:
-the safety information of acid is limited, but general laboratory safety procedures should be followed when handling and using.
-It may be irritating to the eyes, skin and respiratory tract, so wear appropriate personal protective equipment, such as safety glasses and gloves.
-The storage and handling of oxidizing chemicals should be carried out in accordance with local regulations.
