1H-Indazole-7-carboxamide(CAS#312746-74-0)
Introduction
1H-Indazole-7-carboxamide (9CI)) is an organic compound. The following is a detailed introduction to the properties, uses, preparation methods and safety information of this compound:Quality:- Appearance: 1H-7-formylinazole is a white to light yellow solid.- Solubility: Slightly soluble in ethanol and chloroform, almost insoluble in water.Use:- One of the main uses of 1H-7-formylindazole is as an intermediate in organic synthesis. It can be used in the synthesis of indazoles and other related compounds.Method:- The preparation method of 1H-7-formylindazole can be obtained by the reaction of indazole and formyl chloride. The reaction conditions are generally carried out at room temperature.- The specific synthesis process involves the technical details of organic synthesis and the selection of reagents, which need to be carried out under laboratory conditions.Safety Information:- There is limited safety data on 1H-7-formylindazole, and safety measures such as wearing gloves and goggles are required when using this compound.- There have been no reports of toxicity and harm to humans of 1H-7-formylindazole.
Application
1H‑Indazole‑7‑carboxamide (CAS 312746‑74‑0) is a privileged heterocyclic building block for medicinal chemistry and pharmaceutical R&D. Its indazole core acts as a purine/phenol bioisostere, while the carboxamide group provides hydrogen‑bonding capacity for tight target engagement. This advanced scaffold is a key intermediate for selective nNOS (neuronal nitric oxide synthase) inhibitors for neurodegenerative diseases, potent PARP inhibitors based on the MK‑4827 chemotype, and IDO1 immunomodulators. The amide handle enables facile diversification via amidation, hydrolysis, or cross‑coupling, supporting rapid SAR studies and fragment‑based lead optimization. Its derivatives demonstrate broad anticancer activity against renal cell carcinoma, solid tumors, and leukemia, as well as anti‑inflammatory, analgesic, antifungal, and antimicrobial effects. High purity ensures reproducible results for high‑throughput screening and cGMP manufacture. Xinchem offers flexible custom synthesis, custom chemical synthesis, and contract manufacturing of 1H‑Indazole‑7‑carboxamide with reliable scaling from R&D grams to commercial tons. Contact us for a competitive quote.
