4-(4-Fluorobenzylamino)-1-methylpiperidine(CAS#359878-47-0)

Introduction

4-(4-fluorobenzylamino)-1-methylpiperidine is an organic compound.The compound is a white crystalline solid with a special amino and piperidine structure. It is stable at room temperature and soluble in a variety of organic solvents such as methanol, ethanol and dimethylformamide.The compound is also used to study the role of neurotransmitters and the affinity of ligands.The method for preparing 4-(4-fluorobenzylamino)-1-methylpiperidine can be obtained by the reaction of piperidine and 4-fluorobenzylamine. A commonly used synthesis method is to react 4-fluorobenzylamine with piperidine in ethanol and heat it to obtain the target product.Appropriate precautions should be taken during handling and handling, such as wearing safety glasses, gloves and protective clothing. It should be stored in a cool, dry place to avoid contact with oxidants and strong acids. The safety data of the compound should be detailed before use and proper operating procedures should be followed.

Application
4-(4-Fluorobenzylamino)-1-methylpiperidine (N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine, CAS 359878-47-0) is a key pharmaceutical intermediate. It is the central building block for the synthesis of Pimavanserin (Nuplazid®), a first-in-class atypical antipsychotic acting as a selective inverse agonist of the serotonin 5‑HT₂A receptor and approved for the treatment of Parkinson’s disease psychosis. In industrial manufacturing, the compound is prepared by reductive amination of 1-methyl-4-piperidone with 4-fluorobenzylamine using nickel‑ or cobalt‑based catalysts. As an essential synthetic precursor, it serves as the main pharmaceutical intermediate for the API in the convergent route to Pimavanserin and is also applied as an organic building block for CNS drug discovery and in the development of other piperidine-based therapeutic agents. Xinchem is a premier manufacturer and supplier of this crucial pimavanserin intermediate. We offer flexible custom synthesis, custom chemical synthesis, and reliable contract manufacturing of high‑purity material, scaling seamlessly from R&D gram quantities to commercial metric tons, with full analytical support and regulatory compliance. Contact us today for a competitive quote and dependable global supply.