7-Indazole Carboxylic Acid Methyl Ester(CAS#755752-82-0)
| WGK Germany | 3 |
Introduction
Methyl 1H-indazole-7-carboxylic acid is an organic compound. It is a white or yellowish solid.Its derivatives have potential pharmacological activities such as antibacterial, antiviral and anticancer, and are of great value in the research and development of new drugs.Preparation of methyl 1H-indazole-7-carboxylic acid is usually obtained by the reaction of indazole with formyl chloride. Specifically, pyridine can be added to the indazole solution, followed by a slow addition of formyl chloride, and the reaction is carried out at the appropriate temperature. The target product is obtained through steps such as crystallization, filtration, and washing.Safety information: Methyl 1H-indazole-7-carboxylate should be avoided from contact with skin and eyes, and protective gloves and safety glasses should be worn if necessary. Pay attention to protective measures when using and handling, and follow the operating procedures of relevant chemicals. In case of accidental contact or inhalation, seek medical attention immediately.
Application
7-Indazole Carboxylic Acid Methyl Ester (CAS 755752-82-0), also known as Methyl 1H-indazole-7-carboxylate, is a functionalized heterocyclic building block valued for its indazole core. It is a key pharmaceutical intermediate in the synthesis of Niraparib (MK-4827), an FDA-approved PARP inhibitor for treating ovarian, breast, and pancreatic cancers. The compound is also used to develop potent CHK1/CHK2 kinase inhibitors targeting DNA repair pathways in cancer therapy. It exhibits significant antimicrobial activity against Gram-positive bacteria (e.g., Staphylococcus aureus and Bacillus subtilis) and fungi (e.g., Candida albicans) by binding to the 50S ribosomal subunit to inhibit protein synthesis. In agricultural chemistry, it serves as a building block for synthesizing advanced herbicides and pesticides, enhancing crop protection profiles. Its unique structure allows exploration in material science for creating specialty polymers and durable coatings. Additionally, it serves as an analytical reference standard for the accurate quantification of indazole-based compounds in complex mixtures. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 7-Indazole Carboxylic Acid Methyl Ester with reliable global supply, flexible from R&D grams to commercial tons. Contact us today for a competitive quote.
