N-tert-butyl-1H-indazole-7-carboxamide(CAS#1476776-76-7)

Introduction

N-tert-butyl-1H-indazole-7-carboxamide is an organic compound.Quality:N-tert-butyl-1H-indazole-7-carboxamide is solid and has a white to off-white color. The compound is stable at room temperature but insoluble in water.Use:N-tert-butyl-1H-indazole-7-carboxamide is commonly used as an intermediate in organic synthesis.Method:The preparation of N-tert-butyl-1H-indazole-7-carboxamide is usually carried out by organic synthesis methods. The specific method can be adapted to specific needs and conditions, and generally involves the reaction of an indazole derivative with the corresponding reaction reagent under suitable reaction conditions, and a purification and crystallization step is performed.Safety Information:

Application
N-tert-butyl-1H-indazole-7-carboxamide (CAS 1476776-76-7) is a key pharmaceutical intermediate and heterocyclic building block widely used in medicinal chemistry and drug discovery. As a derivative of indazole, a privileged scaffold that acts as a bioisostere of phenol with enhanced lipophilicity and metabolic stability, this compound exhibits significant biological activities including anti-tumor, analgesic, anti-inflammatory, and antibacterial properties. It is primarily utilized as an advanced intermediate in the synthesis of Niraparib (Zejula), a potent PARP inhibitor approved for the treatment of epithelial ovarian, fallopian tube, and primary peritoneal cancer. The compound’s indazole core and tert-butyl carboxamide group enable it to serve as a protective group for nuclease cleavage sites, preventing rapid drug degradation in the body to improve activity and stability. It has also shown potential as a lead compound in the development of indole antibiotics for treating bacterial infections. Beyond pharmaceutical applications, this versatile intermediate has been investigated as a plant growth regulator promoting seed germination, root growth, and stress tolerance in crops, as well as for insecticidal and fungicidal activities. Additionally, it functions as a ligand to form coordination complexes with transition metals, exhibiting magnetic, luminescent, and catalytic properties for material science applications. Xinchem provides reliable custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity N-tert-butyl-1H-indazole-7-carboxamide, offering flexible scaling from R&D research quantities to commercial production volumes. Contact us for a competitive quote and global supply.