pyrimidine-2-carbaldehyde(CAS#27427-92-5)
| Hazard Symbols | Xi - Irritant |
| HS Code | 29335990 |
Introduction
pyrimidine-2-carbaldehyde is an organic compound with the chemical formula C5H4N2O.
Nature:
pyrimidine-2-carbaldehyde is a colorless liquid with a strong pungent odor. It is an unstable compound that is prone to polymerization.
Use:
pyrimidine-2-carbaldehyde is often used as an intermediate in organic synthesis. It can be used to prepare pyrimidine compounds and other important raw materials in organic synthesis reactions.
Method:
pyrimidine-2-carbaldehyde can be prepared by using 2-Pyrimidine as starting material, through oxidation reaction or carbonylation synthesis reaction. One of the common preparation methods is to expose 2-pyrimidine and oxygen to ultraviolet light for oxidation.
Safety Information:
pyrimidine-2-carbaldehyde is an irritating compound and direct contact with skin and eyes should be avoided. Wear appropriate personal protective equipment such as gloves and goggles when handling. In addition, it should be operated in a well-ventilated area to avoid inhaling its vapors. For its storage and handling also need to comply with the relevant safety procedures.
Application
Pyrimidine-2-carbaldehyde (CAS 27427-92-5) is a versatile heterocyclic aldehyde widely used as a key intermediate in pharmaceutical and agrochemical R&D. The reactive formyl group at the 2-position enables facile condensation reactions (e.g., reductive amination, Wittig, Grignard addition, and Knoevenagel) to construct diverse pyrimidine-based drug candidates. This building block is essential for synthesizing kinase inhibitors (including JAK, BTK, and CDK inhibitors), antiviral agents (e.g., HIV-1 integrase inhibitors), and antibacterial compounds. It also serves as a precursor for Schiff base ligands in coordination chemistry and for metal-organic frameworks (MOFs). In agrochemistry, its derivatives are used to develop herbicides and fungicides. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of pyrimidine-2-carbaldehyde with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
