6-bromopyrimidin-4-amine(CAS#1159818-57-1)
Introduction
6-Bromo-4-aminopyrimidine is an organic compound. The following is an introduction to its properties, uses, manufacturing methods and safety information:Properties: It is stable at room temperature but decomposes at high temperatures. This compound is a type of organohalopyrimidines.Uses: It is often used as a catalyst, an intermediate in organic synthesis and a research reagent.Method:The preparation of 6-bromo-4-aminopyrimidine is often carried out by the bromination reaction of pyrimidine. The specific preparation method can be obtained by reacting 4-aminopyrimidine with brominating agents (such as phosphorus bromide) under suitable reaction conditions.Safety Information: It is toxic and care should be taken when handling and storing to avoid contact with skin, eyes, and inhalation. When it comes to waste disposal, local rules and regulations should be followed. It should be a relatively safe compound under normal use and storage conditions. The specific safety of use and storage needs to be further confirmed according to the actual situation and local regulations.
Application
6-Bromopyrimidin-4-amine (CAS 1159818-57-1) is a versatile heterocyclic building block featuring a bromine atom at the 6-position and an amino group at the 4-position of the pyrimidine ring. This scaffold is widely used in medicinal chemistry and drug discovery for the synthesis of kinase inhibitors (e.g., JAK, BTK, CDK, PI3K inhibitors), antiviral agents, and anticancer compounds. The bromine enables efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira) to introduce diverse aryl, heteroaryl, or alkyl substituents, while the primary amine allows acylation, alkylation, or amide formation for rapid structure-activity relationship (SAR) studies. Its rigid pyrimidine core provides excellent metabolic stability and target binding affinity. This compound is also utilized in the development of antibacterial, antifungal, and anti-inflammatory agents, as well as agrochemicals (herbicides, fungicides). High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of 6-bromopyrimidin-4-amine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
