2-Bromo-4-fluorophenol(CAS#496-69-5)

Introduction

2-Bromo-4-fluorophenol is an organic compound. The following is an introduction to the properties, uses, preparation methods and safety information of 2-bromo-4-fluorophenol:Properties:- Appearance is a white crystalline solid- Relative molecular weight is 207.99 g/mol- Soluble in alcohol, ether and ether solvents, insoluble in water- is a strong oxidizing agent- It decomposes at high temperatures, producing toxic gasesUses:- 2-Bromo-4-fluorophenol can be used as an intermediate in dyes and pigments- Can be used to synthesize biologically active compounds- It can also be used for catalyst and electrode surface modification methods in electrochemical research:- The synthesis of 2-bromo-4-fluorophenol is generally obtained by reacting para-bromofluorobenzene (C6H4BrF) with sodium hydroxide (NaOH)- The reaction can be carried out at room temperature or under heating conditions- After the reaction, 2-bromo-4-fluorophenol product is obtained by acidification and purificationSafety information:- 2-Bromo-4-fluorophenol is toxic and may cause irritation and harm to the human body- May cause inflammation and irritation in contact with the skin and eyes- Inhalation or ingestion may cause respiratory and gastrointestinal irritation- Personal protective equipment such as gloves, goggles, and protective clothing should be worn when using and handling- Should be kept away from fire and high temperatures- When using, please refer to the relevant safety instructions and operating instructions, and use with caution

Application
2-Bromo-4-fluorophenol is a functionalized dihalogenated phenol widely used as a versatile building block in pharmaceutical and agrochemical research. The ortho-bromo and para-fluoro substituents enable orthogonal chemoselective transformations: the bromine undergoes efficient palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), while the fluorine enhances metabolic stability, lipophilicity, and target binding affinity. This compound serves as a key pharmaceutical intermediate for the synthesis of kinase inhibitors, antiviral agents, and antibacterial drug candidates. In agrochemical development, it is a critical precursor for novel fungicides and herbicides with improved crop protection profiles. Its phenolic OH allows further derivatization via etherification or esterification. High purity ensures reproducible results in structure-activity relationship studies, high-throughput screening, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 2-bromo-4-fluorophenol to meet your R&D and commercial needs. Contact us for a competitive quote and reliable global supply.