2-(Chloromethyl)[1,3]oxazolo[4,5-b]pyridine(CAS#110704-34-2)

Introduction

2-(Chloromethyl)[1,3]oxazolo[4,5-b]pyridine is an organic compound with the chemical formula C8H6ClNO. Its molecular structure contains the ring structure of oxazole and pyridine, and there is a chloromethyl substituent on the oxazole.

2-(Chloromethyl)[1,3]oxazolo[4,5-b]pyridine is a colorless to pale yellow solid crystalline material at room temperature. It has high thermal stability and solubility, and can be dissolved in a variety of organic solvents.

This compound is often used in organic synthesis reactions as a catalyst, ligand or intermediate. It can be used to synthesize other organic compounds, such as olefins, ketones, alcohols, etc., and has a wide range of applications.

The method for preparing 2-(Chloromethyl)[1,3]oxazolo[4,5-b]pyridine is usually to react oxazole with chloromethanol, and then perform the pyridine ring construction under basic conditions.

Regarding its safety information, 2-(Chloromethyl)[1,3]oxazolo[4,5-b]pyridine is an organic compound that may pose a potential hazard to human health. Appropriate personal protective measures, such as wearing chemical protective gloves and glasses, should be taken during operation to avoid contact with skin and eyes. To avoid inhaling its dust or gas, it should be operated in a well-ventilated place. When stored, keep it away from fire and oxidant, and keep it sealed and dry.

Application
2-(Chloromethyl)[1,3]oxazolo[4,5-b]pyridine (CAS 110704-34-2) is a functionalized fused heterocycle containing a reactive chloromethyl group. This alkylating reagent is widely used in medicinal chemistry as a versatile building block for the synthesis of kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., PI3K, CDK, and EGFR inhibitors). The chloromethyl moiety enables efficient nucleophilic substitution with amines, thiols, and alcohols to introduce the rigid oxazolopyridine scaffold into drug-like architectures. The fused ring system enhances metabolic stability and target binding affinity. This intermediate also serves as a precursor for antiviral, antibacterial, and antifungal agents, as well as for agrochemicals and functional materials. Its high reactivity allows rapid structure-activity relationship (SAR) studies and library construction. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.