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Oxazolo[4,5-c]pyridin-2-amine(CAS#114498-55-4)
Introduction
2-Aminopyridinoxazole. It is an organic substance with a white to yellowish crystalline solid form.This compound is commonly used as a reagent or intermediate in organic synthesis reactions. Its structure contains two rings, pyridine and oxazole, which makes it have certain activity and diverse reactivity.2-Aminopyridoxazole can be prepared by a variety of methods. One of the commonly used methods is to react 2-aminopyridine with chloroacetic anhydride and perform a cyclization reaction under acidic conditions to obtain the target product.Based on the available information, the effects of the compound on human health are not known and appropriate precautions should be taken when using it, such as wearing gloves, goggles, and protective clothing. Avoid contact with the skin and inhalation of its dust, and avoid accidental ingestion or inhalation.
Application
Oxazolo[4,5-c]pyridin-2-amine (CAS 114498-55-4) is a nitrogen-rich fused bicyclic heterocycle containing an oxazole ring fused to a pyridine moiety. This scaffold has garnered significant attention in medicinal chemistry as a core structure for developing potent kinase inhibitors, particularly as a 2-amino-isoxazolopyridine series targeting Polo-like kinase 1 (Plk1) for oncology and anti-inflammatory indications. As a versatile building block, it enables the synthesis of a wide range of pharmaceuticals, agrochemicals, and functional materials. The oxazole ring is a valuable heterocyclic scaffold for designing novel therapeutics with anticancer, antiviral, antibacterial, anti-inflammatory, neuroprotective, antidiabetic, and antidepressant properties. The free amine group at the 2-position allows facile derivatization via amide coupling, urea formation, or heterocycle annulation for rapid structure-activity relationship (SAR) studies. The rigid, planar oxazolopyridine core enhances metabolic stability and target binding affinity. High purity ensures reproducible results in high-throughput screening and scalable GMP manufacturing. Xinchem offers custom synthesis and contract manufacturing of Oxazolo[4,5-c]pyridin-2-amine with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
