4-(chloromethyl)-3,5-dimethylisoxazole(CAS#19788-37-5)
Safety Information
Signal word: warning
Hazard Statement: H302 + H312 + H332; H315； H319； H335
Cautionary Statement: P261; P280； P305 + P351 + P338
Risk Category Codes: R20/21/22
Safety Instructions: S26 - S36
Hazard Signs: XN; XI
WGK Germany：3
Uses: It is an organic synthesis intermediate, which can be used to synthesize a variety of compounds with potential biological activity or special uses, such as participating in asymmetric isoxazole cyclization reaction, and can also be used to prepare 4-(3-oxoalkyl)isoxazole, (E)-3,5-dimethyl-4-(2-(thiophene-3-yl)vinyl)isoxazole, etc
Application
4-(Chloromethyl)-3,5-dimethylisoxazole (CAS 19788-37-5) is a functionalized heterocyclic building block featuring a reactive chloromethyl group on a 3,5-dimethylisoxazole ring. This alkylating agent is widely used in medicinal chemistry for the synthesis of bioactive molecules, including kinase inhibitors (e.g., p38 MAPK, PI3K, and EGFR inhibitors), antimicrobial agents, and anti-inflammatory drug candidates. The chloromethyl moiety enables efficient nucleophilic substitution with amines, thiols, alcohols, and carboxylates, allowing rapid introduction of the isoxazole scaffold into complex drug-like structures. The 3,5-dimethyl substitution enhances metabolic stability and lipophilicity. This intermediate also serves as a key precursor for agrochemicals (herbicides, fungicides), as well as for functional materials and ligands in coordination chemistry. Its rigid, electron-rich isoxazole core provides target binding affinity and metabolic resistance. High purity ensures reproducible results in high-throughput screening, structure-activity relationship (SAR) studies, and scalable GMP manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
