3-Chloroisoquinoline(CAS#19493-45-9)
| Hazard Symbols | Xi - Irritant |
| Hazard Note | Irritant |
Introduction
3-Chloroisoquinoline(3-Chloroisoquinoline) is an organic compound with the chemical formula C9H6ClN. The following is a brief description of the nature, use, preparation and safety information of 3-Chloroisoquinoline:
Nature:
-Appearance: 3-Chloroisoquinoline is a white to light yellow crystal or crystalline powder.
-Solubility: 3-Chloroisoquinoline is soluble in Ketone solvents, ether and dichloromethane, and slightly soluble in alcohol solvents.
-Melting point: about 48-50 ℃.
-Spectroscopic data: The nuclear magnetic resonance hydrogen spectrum (NMR) and infrared spectrum (IR) of 3-Chloroisoquinoline can provide characteristic information for its structure.
Use:
-as an intermediate: 3-Chloroisoquinoline can be used for the synthesis of a variety of pharmaceutical and pesticide intermediates, such as for the synthesis of anti-epileptic drugs, antidepressants, anticancer drugs and pesticides.
Method:
-o-dinitro aromatic compound method: 3-Chloroisoquinoline is prepared by nitration and chlorination of O-diamino aromatic compounds.
-imidazole base method: the imidazole base is reacted with substituted acetophenone, and then cyclization reaction is carried out to obtain 3-Chloroisoquinoline.
Safety Information:
-Toxicity: 3-Chloroisoquinoline may cause damage to the human body when exposed or ingested in large quantities, and has certain toxicity. Care should be taken to avoid inhalation, ingestion or skin contact.
-flammability: 3-Chloroisoquinoline is a combustible substance, which may cause combustion or explosion in case of fire source, so it should be kept away from open flame and high temperature.
-Environmental impact: 3-Chloroisoquinoline has a certain environmental impact, and waste materials should be properly disposed of in accordance with regulations.
Application
3-Chloroisoquinoline (CAS 19493-45-9) is a functionalized heterocyclic building block featuring a chlorine atom at the 3-position of the isoquinoline core. It is widely used in medicinal chemistry and drug discovery for the synthesis of bioactive molecules, including potent kinase inhibitors targeting cancer, inflammation, and neurological disorders. The chlorine enables selective nucleophilic aromatic substitution and palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), allowing rapid introduction of diverse aryl, heteroaryl, or alkyl substituents for structure-activity relationship (SAR) studies. This scaffold serves as a key intermediate for developing anticancer agents, antiviral drugs, antimicrobial compounds, and central nervous system (CNS) therapeutics. It is also utilized in the synthesis of fluorescent probes, agrochemicals, and functional materials. High purity ensures reproducible results in high-throughput screening and scalable pharmaceutical manufacturing. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of high-purity 3-chloroisoquinoline with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
