7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline(CAS#199678-32-5)
Introduction
7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline is an organic compound with the molecular formula C10H13F3N and the structural formula:
! [7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline](https://upload.wikimedia.org/wikipedia/commons/f/f8/7(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline.svg)
Nature:
1. Appearance: 7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline is a white or light yellow crystalline solid.
2. Melting Point: about 61-64 ℃.
3. Boiling point: About 155-156 ℃.
4. Density: about 1.228 g/cm.
5. Solubility: Soluble in alcohol, ether and ether solvent.
Use:
7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline is an organic synthetic compound that can be used to synthesize drugs, pesticides and other organic compounds. It can be used as an intermediate for antipsychotic and sedative drugs, as a hydrogenation reagent in organic synthesis, and as a catalyst for Heterocyclic Synthesis.
Method:
7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline can be prepared in a variety of ways. Common methods include:
1. Reacting trifluoromethyl butyl ether with aniline in the presence of aluminum chloride, and obtaining the target product through hydrogenation reaction;
2.1,2,3,4-tetrahydroisoquinoline is reacted with a trifluoromethylating reagent (such as trifluoromethyliodomethane) under basic conditions to yield 7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline.
Safety Information:
When using or handling 7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline, the following safety precautions should be observed:
1. Avoid inhalation, ingestion or contact with skin and eyes. Wear appropriate protective equipment such as gloves, goggles and protective clothing.
2. Maintain good ventilation conditions and avoid dust, smoke or vapor during operation.
3. Should be stored in a sealed container, placed in a cool, dry place, away from the fire and oxidant.
4. Waste shall be disposed of in accordance with relevant regulations. For large spills or accidents, appropriate clean-up and disposal measures should be taken, following standard operating procedures for chemical spills and waste disposal.
Application
7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline (CAS 199678-32-5) is a high-purity, functionalized tetrahydroisoquinoline (THIQ) derivative featuring a lipophilic trifluoromethyl group at the 7-position. This privileged scaffold is widely used in medicinal chemistry and drug discovery as a key intermediate for the synthesis of central nervous system (CNS) agents, including potential therapeutics for Parkinson’s disease, Alzheimer’s disease, depression, and anxiety disorders. The CF3 group enhances metabolic stability and blood-brain barrier penetration, while the rigid THIQ core provides optimal target binding. It also serves as a building block for kinase inhibitors, GPCR modulators, and neuroprotective agents. In pharmaceutical R&D, this intermediate enables rapid structure-activity relationship (SAR) studies. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this versatile compound with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
