phenothiazine-2-carbonitrile(CAS#38642-74-9)
Introduction
phenothiazine-2-carbonitrile is an organic compound containing a phenothiazine nucleus and a cyano group in its structure. The following is a description of its nature, use, formulation and safety information:
1. nature:
-Appearance: The phenothiazine-2-carbonitrile is a powdery or crystalline solid.
-Solubility: It can be dissolved in anhydrous ethanol, chloroform and dimethyl sulfoxide, and slightly soluble in water.
-Melting point: about 177-181 ℃.
2. use:
-Pharmacology: phenothiazine-2-carbonitrile is an important organic synthesis intermediate, which can be used to synthesize a variety of drugs and physiologically active substances, such as anti-cancer drugs, antibacterial drugs and antidepressants.
-Dye: It can be used as a starting material for the synthesis of organic dyes.
-Photoelectric materials: phenothiazine-2-carbonitrile have application potential in organic photoelectric materials.
3. Preparation method:
- phenothiazine-2-carbonitrile can be prepared by the reaction of 2-phenothiazine methanol with hydrocyanic acid. The reaction conditions generally require appropriate acid catalysts.
4. Safety Information:
- phenothiazine-2-carbonitrile in the suspended air may produce explosive combustible gas.
-It is irritating to the eyes and skin and should be avoided.
-Use appropriate safety equipment during operation, including protective glasses, protective gloves and respiratory protection.
-In storage and handling, to avoid fire and high temperature environment, to ensure good ventilation. Proper disposal and waste management practices should be followed.
Application
Phenothiazine-2-carbonitrile (2-Cyanophenothiazine, CAS 38642-74-9) is a key drug intermediate widely used in the synthesis of various antipsychotic agents, including Cyamemazine (an anxiolytic and antipsychotic compound) and Periciazine (a typical antipsychotic for treating schizophrenia and other psychotic disorders). Beyond medicinal chemistry, this phenothiazine scaffold serves as a versatile building block for constructing antibacterial, anticancer, and antidepressant drug candidates. The nitrile group enables further functionalization via reduction to amine or conversion to tetrazole, while the phenothiazine core exhibits intrinsic bioactivity and electrochemical properties. In material science, phenothiazine-2-carbonitrile shows application potential in organic photoelectric materials, electroactive compounds, and organic semiconductors. It also serves as a starting material for the synthesis of organic dyes. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this high-purity heterocyclic building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.







