3-Bromo-5-chlorobenzotrifluoride(CAS#928783-85-1)

3-Bromo-5-chlorobenzotrifluoride(CAS#928783-85-1) Introduction

It is an organic compound with the chemical formula C7H3BrClF3. The following is a description of its nature, use, preparation and safety information:

Nature:
is a colorless to pale yellow liquid. It has low solubility and low volatility. It is an organic halogenated hydrocarbon compound with certain volatility and strong chemical stability. It is stable at room temperature and is not easily affected by moisture.

Use:
It is widely used as a reagent in organic synthesis. It can be used as a protective group for amines and alcohols and used in the synthesis of other organic compounds. In addition, it can also be used to prepare organic compounds such as drugs, dyes and pesticides.

Method:
In general, it can be synthesized by Bromination and chlorination of toluene, followed by trifluoromethylation. There are many methods for specific reaction conditions, which are not enumerated here.

Safety Information:
It is an organic compound, so you need to pay attention to safety measures when handling and using it. It is less volatile, but may still cause irritation to the eyes, skin, and respiratory system. Therefore, direct exposure should be avoided at the time of contact and appropriate personal protective equipment should be used. When storing and handling, please operate in a well-ventilated place. In addition, it is also a flammable liquid and should be kept away from fire and high temperature. If necessary, the corresponding safety procedures shall be followed.

Application
3-Bromo-5-chlorobenzotrifluoride (1-bromo-3-chloro-5-(trifluoromethyl)benzene, CAS 928783-85-1) is a multifunctional, polyhalogenated aromatic building block. Its unique meta-substitution pattern featuring bromine, chlorine, and a strong electron-withdrawing trifluoromethyl (CF₃) group offers orthogonal reactivity for chemoselective transformations: the bromine atom serves as an excellent handle for palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Buchwald-Hartwig, Sonogashira), while the chlorine remains inert, enabling sequential functionalization. This compound serves as a key pharmaceutical intermediate and has been utilized in the preparation of anti-infective agents such as LpxH inhibitors and fumarate derivatives. In agrochemical research, this advanced intermediate is a key precursor for synthesizing novel amide derivatives with potent insecticidal and broad-spectrum pesticidal activity, effectively controlling biological crop pests. Beyond life sciences, the compound is employed as a core building block for liquid crystal materials, specialty dyes, and high-performance polymers, where its halogenated aromatic structure enhances thermal stability and chemical resistance. The trifluoromethyl group further enhances the metabolic stability, lipophilicity, and bioavailability of target molecules, making this building block highly valuable in medicinal chemistry, custom synthesis, and process R&D. Xinchem offers high-purity 3-Bromo-5-chlorobenzotrifluoride with reliable custom synthesis and flexible contract manufacturing, scalable from R&D to commercial tons. Contact us for a competitive quote and global supply.