4-Aminoisoxazole(CAS#108511-97-3)

Introduction

4-Aminoisoxazole is an organic compound.4-Aminoisoxazole is a colorless crystal that is soluble in water and some organic solvents such as ethanol and acetone at room temperature. It is strongly alkaline and can have a neutralizing reaction with acids.4-aminoisoxazole has a variety of uses. It can be used as an intermediate in organic synthesis to participate in a variety of chemical reactions, such as oxidation, alkylation and amination. 4-aminoisoxazole can also be used in pesticide synthesis and dye preparation.There are two main methods for preparing 4-aminoisoxazole. One is through the nitrogen-iodination reaction of isoxazole, 4-bromoisooxazole is prepared first, and then 4-aminoisooxazole is obtained through the substitution reaction of bromine. Another method is to react adipic anhydride with nitrous acid to generate 4-nitrosoisooxazole, which is then reduced by hydrogenation to obtain 4-aminoisooxazole.Safety information: 4-aminoisoxazole does not cause obvious acute toxicity to humans under normal circumstances. However, it may have an irritating effect on the eyes and skin, and precautions should be taken when using it to avoid direct contact. Good laboratory practice is followed during operation and proper ventilation measures are taken. If it is inhaled or touched, it should be cleaned or treated with medical attention in time.

Application
4-Aminoisoxazole (CAS 108511-97-3) is a privileged heterocyclic primary amine building block containing a five-membered ring. It is utilized in drug discovery for the design and synthesis of hydroxyethylene-based HIV-1 protease inhibitors containing a heterocyclic P1'-P2' amide bond isostere, and also serves as a reactant in the synthesis of pyrimidine derivatives that act as selective Janus kinase 3 (JAK3) inhibitors. The heterocyclic scaffold also demonstrates potential interactions with the GABA A receptor, making it a valuable lead for epilepsy, anxiety, and sleep disorder research. As a versatile reactant, 4-aminoisoxazole serves as an essential intermediate in the synthesis of complex heterocyclic systems and exhibits anticancer activity against tumor cell lines. High purity ensures reproducible results in high-throughput screening and SAR studies. Xinchem is a premier manufacturer and supplier of 4-Aminoisoxazole, offering flexible custom synthesis and contract manufacturing solutions for pharmaceutical R&D, agrochemical, and material science applications. Contact us today for a competitive quote and reliable global supply.