4-iodo-3,5-dimethylisoxazole(CAS#10557-85-4)
| Risk Codes | 41 - Risk of serious damage to eyes |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S39 - Wear eye / face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| HS Code | 29349990 |
| Hazard Class | LIGHT SENSITIVE |
Introduction
3,5-Dimethyl-4-iodoisoxazole is an organic compound.Quality:- Appearance: Colorless crystals or crystalline powders- Solubility: Soluble in chloroform, ethanol and ether, slightly soluble in waterUses: It can be used in agriculture to control crop diseases such as corn, wheat and grapes. It is also used as a mordant in industry.Method:The preparation of 3,5-dimethyl-4-iodoisoxazole can be obtained by the reaction of 2-acetylamino-4,6-dibromobenzene and methyl acetate under alkaline conditions, and by ammonia decarboxylation.Safety Information:3,5-dimethyl-4-iodoisoxazole is a toxic compound that may be irritating to the skin and eyes upon exposure. Protective gloves and goggles should be worn when in use, and care should be taken to avoid inhalation or contact. Store in a cool, well-ventilated place, away from fire and oxidants. When disposing of waste, it is necessary to dispose of it in accordance with local laws and regulations to avoid pollution to the environment.
Application
4-Iodo-3,5-dimethylisoxazole (CAS 10557-85-4) is a versatile heteroaryl iodide building block widely used in medicinal chemistry and drug discovery. The iodine atom at the 4-position enables efficient palladium-catalyzed cross-coupling reactions including Suzuki-Miyaura, Sonogashira, Buchwald-Hartwig, and Stille couplings, allowing rapid introduction of diverse aryl, alkynyl, amino, or alkyl substituents into the isoxazole core. The 3,5-dimethyl groups provide steric and electronic modulation, enhancing metabolic stability and target selectivity. This privileged scaffold serves as a key intermediate for the synthesis of potent kinase inhibitors targeting cancer, inflammation, and autoimmune diseases (e.g., p38 MAPK, PI3K, and CDK inhibitors). It is also utilized in the development of antiviral, antibacterial, and antifungal agents, as well as in agrochemical research for herbicides and fungicides. The rigid isoxazole ring improves target binding affinity and pharmacokinetic properties. High purity ensures reproducible results in high-throughput screening, structure-activity relationship studies, and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
