3-Methyl-2-nitrobenzoic acid(CAS#5437-38-7)

Introduction

3-Methyl-2-nitrobenzoic acid, also known as p-methylnitrobenzoic acid, is an organic compound. The following is an introduction to its nature, use, preparation method and safety information:Quality:- Appearance: 3-methyl-2-nitrobenzoic acid is white or light yellow crystal;- Solubility: Soluble in ethanol, chloroform and ether organic solvents, insoluble in water.Use:- Fuel additives: can be used as explosion suppressants in some fuels.Method:3-Methyl-2-nitrobenzoic acid can be prepared by nitrification of p-methylbenzoic acid.Safety Information:- 3-methyl-2-nitrobenzoic acid is an organic compound that can be dangerous;- Avoid direct contact with the skin and eyes, avoid inhalation and ingestion;- Wear personal protective equipment such as safety glasses, gloves and face shields during use;- When storing, it should be stored tightly sealed, away from fire and oxidants.

Application
3-Methyl-2-nitrobenzoic acid is a high-purity nitroaromatic building block and versatile synthetic intermediate widely used in organic synthesis and pharmaceutical research. As a key pharmaceutical intermediate, it serves as a precursor for the synthesis of novel Indolin-2-one derivatives as protein tyrosine phosphatase 1B inhibitors. It is also utilized as Niraparib Impurity 10, a critical reference standard for analytical method development, method validation (AMV), quality control (QC), and ANDA filings during commercial production of the anticancer drug Niraparib. The ortho-nitro group relative to the methyl substituent and carboxylic acid functionality make this compound valuable for metal-catalyzed cross-coupling reactions and the synthesis of heterocyclic systems including benzodiazepine and quinazoline scaffolds. Its derivatives are further applied in dye production, agrochemicals, and as a chromatographic standard. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential building block with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.