2-Methyl-3-nitrobenzoic acid(CAS#1975-50-4)
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29163900 |
| Hazard Note | Irritant |
Introduction
2-Methyl-3-nitrobenzoic acid is an organic compound. The following is an introduction to its nature, use, preparation method and safety information:Quality:- Appearance: 2-Methyl-3-nitrobenzoic acid is a pure white crystal or light yellow powder.- Solubility: It has a low solubility in water but can be dissolved in organic solvents such as ethanol and chloroform.- Chemical properties: It is an acidic compound that reacts with alkali to form the corresponding salt.Use:- Chemical reagents: 2-methyl-3-nitrobenzoic acid is often used as an intermediate and chemical reagent in organic synthesis.Method:2-Methyl-3-nitrobenzoic acid can be prepared by the reaction of benzoic acid and nitrous acid. Under acidic conditions, nitrous acid is formed into nitrous ions (NO2-). Then, 2-methyl-3-nitrobenzoic acid is formed by the reaction of nitrous ions with benzoic acid.Safety Information:- 2-Methyl-3-nitrobenzoic acid is an organic compound and should be strictly followed by laboratory safety operating procedures.- Avoid direct contact with skin and eyes during use, storage, and handling.- Wear protective gloves, protective glasses, and a lab coat when handling and using 2-methyl-3-nitrobenzoic acid.- When used in a laboratory or industrial setting, ensure that there is a good ventilation system in place to prevent the accumulation of gases or vapors.- In case of accidental inhalation, ingestion, or skin contact, seek immediate medical attention and provide product packaging or labeling to a physician.
Application
2-Methyl-3-nitrobenzoic acid (CAS 1975-50-4) is a versatile nitroaromatic building block widely used as a key intermediate in pharmaceutical and agrochemical synthesis. Its carboxylic acid group enables amidation and esterification, while the nitro group can be reduced to an amine for further functionalization. This compound serves as a precursor for non-steroidal anti-inflammatory drugs (NSAIDs), antimicrobial agents, and angiotensin II receptor antagonists. In agrochemistry, it is utilized in the development of selective herbicides and plant growth regulators. It also functions as an impurity reference standard (e.g., Telmisartan Impurity) for analytical method development, method validation, and quality control in API manufacturing. The rigid aromatic core provides metabolic stability, supporting rapid structure-activity relationship (SAR) studies. High purity ensures reproducible results in high-throughput screening and scalable GMP synthesis. Xinchem offers custom synthesis, custom chemical synthesis, and contract manufacturing of this essential intermediate with flexible scaling from R&D to commercial tons. Contact us today for a competitive quote and reliable global supply.
